@article{oai:repo.qst.go.jp:00047096,
 author = {Kimura, Yasuyuki and Ito, Hiroshi and Shiraishi, Takahiro and Fujiwara, Hironobu and Kodaka, Fumitoshi and Takano, Harumasa and Shimada, Hitoshi and Kanno, Iwao and Suhara, Tetsuya and 木村 泰之 and 伊藤 浩 and 白石 貴博 and 藤原 広臨 and 小高 文聰 and 高野 晴成 and 島田 斉 and 菅野 巖 and 須原 哲也},
 issue = {1},
 journal = {Nuclear Medicine and Biology},
 month = {Sep},
 note = {Abstract: Purpose: [11C]FLB 457, a radioligand with very high affinity and selectivity for dopamine D2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of [11C]FLB 457 in healthy human subjects.
Methods: Whole-body images were acquired for 2 h after an injection of [11C]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software.
Results: Organs with the longest residence time were the liver, lungs, and red marrow. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by [11C]FLB 457 is 5.9 microSv/MBq, similar to those of other 11C-labeled tracers. Conclusions: This effective dose would allow multiple scans in the same individual based on prevailing maximum recommended- dose guidelines in the USA and Europe.},
 pages = {102--105},
 title = {Biodistribution and radiation dosimetry in humans of [11C]FLB 457, a positron emission tomography ligand for the extrastriatal dopamine D2 receptor},
 volume = {41},
 year = {2013}
}