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Gadolinium-based nanoparticles to improve the hadrontherapy performances.
https://repo.qst.go.jp/records/47017
https://repo.qst.go.jp/records/470171865d6a3-83ae-4129-ae18-197d67091276
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-01-20 | |||||
| タイトル | ||||||
| タイトル | Gadolinium-based nanoparticles to improve the hadrontherapy performances. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Elica, PORCEL
× Elica, PORCEL× Olivier, TILLEMENT× François, LUX× Pierre, MOWAT× Usami, Noriko× Kobayashi, Katsumi× Furusawa, Yoshiya× Le, Sech Claude× Sandrine, LACOMBE× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nanomedicine is proposed as a novel strategy to improve the performance of radiotherapy. High-Z nanoparticles are known to enhance the effects of ionising radiation. Recently, multimodal nanoparticles such as gadolinium-based nanoagents were proposed not only to amplify the effects of x-rays and γ-rays, but also to improve MRI diagnosis. For tumours sited in sensitive tissues, childhood cases and radioresistant cancers, hadrontherapy is considered superior to x-rays and γ-rays. Hadrontherapy, based on fast ion radiation, has the advantage of avoiding damage to the tissues behind the tumour; however, the damage caused in front of the tumour is its major limitation. Here, we demonstrate that multimodal gadolinium-based nanoparticles amplify cell death with fast ions used as ionizing radiations. Molecular scale experiments give insights into the mechanisms underlying the amplification of radiation effects. This proof-of-concept opens up novel perspectives for multimodal nanomedicine in hadrontherapy, ultimately reducing negative radiation effects in healthy tissues in front of the tumour. | |||||
| 書誌情報 |
NANOMEDICINE - Nanotechnology Biology and Medicine 巻 10, 号 8, p. 1601-1608, 発行日 2014-05 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1549-9634 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24846523 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nano.2014.05.005. | |||||
