{"created":"2023-05-15T14:36:30.490928+00:00","id":47017,"links":{},"metadata":{"_buckets":{"deposit":"d8c82a07-754f-4477-86fc-9e3fd217d5c0"},"_deposit":{"created_by":1,"id":"47017","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47017"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047017","sets":["1"]},"author_link":["469389","469390","469396","469397","469388","469393","469391","469394","469395","469392"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1608","bibliographicPageStart":"1601","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"NANOMEDICINE - Nanotechnology Biology and Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nanomedicine is proposed as a novel strategy to improve the performance of radiotherapy. High-Z nanoparticles are known to enhance the effects of ionising radiation. Recently, multimodal nanoparticles such as gadolinium-based nanoagents were proposed not only to amplify the effects of x-rays and γ-rays, but also to improve MRI diagnosis. For tumours sited in sensitive tissues, childhood cases and radioresistant cancers, hadrontherapy is considered superior to x-rays and γ-rays. Hadrontherapy, based on fast ion radiation, has the advantage of avoiding damage to the tissues behind the tumour; however, the damage caused in front of the tumour is its major limitation. Here, we demonstrate that multimodal gadolinium-based nanoparticles amplify cell death with fast ions used as ionizing radiations. Molecular scale experiments give insights into the mechanisms underlying the amplification of radiation effects. This proof-of-concept opens up novel perspectives for multimodal nanomedicine in hadrontherapy, ultimately reducing negative radiation effects in healthy tissues in front of the tumour.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24846523","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.nano.2014.05.005.","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1549-9634","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Elica, PORCEL"}],"nameIdentifiers":[{"nameIdentifier":"469388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Olivier, TILLEMENT"}],"nameIdentifiers":[{"nameIdentifier":"469389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"François, LUX"}],"nameIdentifiers":[{"nameIdentifier":"469390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Pierre, MOWAT"}],"nameIdentifiers":[{"nameIdentifier":"469391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usami, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"469392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"469393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"469394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Le, Sech Claude"}],"nameIdentifiers":[{"nameIdentifier":"469395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sandrine, LACOMBE"}],"nameIdentifiers":[{"nameIdentifier":"469396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469397","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gadolinium-based nanoparticles to improve the hadrontherapy performances.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gadolinium-based nanoparticles to improve the hadrontherapy performances."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-20"},"publish_date":"2015-01-20","publish_status":"0","recid":"47017","relation_version_is_last":true,"title":["Gadolinium-based nanoparticles to improve the hadrontherapy performances."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:44:53.941705+00:00"}