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Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
https://repo.qst.go.jp/records/47001
https://repo.qst.go.jp/records/470018830d602-723f-487e-bdd6-d9332cb5a7b3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-12-16 | |||||
| タイトル | ||||||
| タイトル | Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
二宮, 康晴
× 二宮, 康晴× 崔, 星× 安田, 武嗣× 王, 冰× 于, 冬× 関根, 絵美子× 根井, 充× 二宮 康晴× 崔 星× 安田 武嗣× 王 冰× 于 冬× 関根 絵美子× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Arsenite is a potent anticancer agent for many human cancers. In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). Arsenite dose-dependently reduced cell growth, and low concentration of arsenite significantly induced γH2AX foci formation both in U87MG-neo and U87MG-E6 cells. However, senescence was induced by arsenite with senescence-associated β-galactosidase staining and dimethyl- and trimethyl-lysine 9 of histone H3 (H3DMK9 and H3TMK9) foci formation accompanied by p21 accumulation only in U87MG-neo, suggesting that arsenite induces premature senescence as a result of DNA damage with heterochromatin formation through p53/p21 dependent pathway. Consistently, p21 and p53 siRNA decreased H3TMK9 foci formation in U87MG-neo treated with arsenite. Taken together, arsenite reduces cell growth p53-independently and induces premature senescence via p53/p21-dependent pathway following DNA damage. This finding explored new anti-tumor mechanisms induced by arsenite. | |||||
| 書誌情報 |
BMB Reports 巻 47, 号 10, p. 575-580, 発行日 2014-02 |
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| 出版者 | ||||||
| 出版者 | Hanʼguk Saenghwahak Punja Saengmul Hakhoe | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1976-6696 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | Feb 6. pii: 2585. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://submit.bmbreports.org/Search/View.html?tr_num=2585&start=0&keyword= | |||||
| 関連名称 | http://submit.bmbreports.org/Search/View.html?tr_num=2585&start=0&keyword= | |||||
