{"created":"2023-05-15T14:36:29.801976+00:00","id":47001,"links":{},"metadata":{"_buckets":{"deposit":"b6e59c33-fdf3-43bc-a928-b7424d891512"},"_deposit":{"created_by":1,"id":"47001","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47001"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047001","sets":["1"]},"author_link":["469174","469177","469180","469183","469172","469182","469175","469181","469179","469176","469178","469170","469173","469171"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"580","bibliographicPageStart":"575","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"BMB Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Arsenite is a potent anticancer agent for many human cancers. In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). Arsenite dose-dependently reduced cell growth, and low concentration of arsenite significantly induced γH2AX foci formation both in U87MG-neo and U87MG-E6 cells. However, senescence was induced by arsenite with senescence-associated β-galactosidase staining and dimethyl- and trimethyl-lysine 9 of histone H3 (H3DMK9 and H3TMK9) foci formation accompanied by p21 accumulation only in U87MG-neo, suggesting that arsenite induces premature senescence as a result of DNA damage with heterochromatin formation through p53/p21 dependent pathway. Consistently, p21 and p53 siRNA decreased H3TMK9 foci formation in U87MG-neo treated with arsenite. Taken together, arsenite reduces cell growth p53-independently and induces premature senescence via p53/p21-dependent pathway following DNA damage. This finding explored new anti-tumor mechanisms induced by arsenite.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hanʼguk Saenghwahak Punja Saengmul Hakhoe"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"Feb 6. pii: 2585. ","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://submit.bmbreports.org/Search/View.html?tr_num=2585&start=0&keyword="}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://submit.bmbreports.org/Search/View.html?tr_num=2585&start=0&keyword=","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1976-6696","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二宮, 康晴"}],"nameIdentifiers":[{"nameIdentifier":"469170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔, 星"}],"nameIdentifiers":[{"nameIdentifier":"469171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田, 武嗣"}],"nameIdentifiers":[{"nameIdentifier":"469172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"469173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"于, 冬"}],"nameIdentifiers":[{"nameIdentifier":"469174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"469175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井, 充"}],"nameIdentifiers":[{"nameIdentifier":"469176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 武嗣","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"于 冬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469183","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-16"},"publish_date":"2014-12-16","publish_status":"0","recid":"47001","relation_version_is_last":true,"title":["Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:06.145930+00:00"}