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Vessel specific imaging of glucose transfer with fluorescent glucose analogue in anesthetized mouse cortex.
https://repo.qst.go.jp/records/46988
https://repo.qst.go.jp/records/46988fd2cc191-7d23-48d6-9db0-68c3ca3024fc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-12-16 | |||||
| タイトル | ||||||
| タイトル | Vessel specific imaging of glucose transfer with fluorescent glucose analogue in anesthetized mouse cortex. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Murata, Rei
× Murata, Rei× Takada, Yuki× Takuwa, Hiroyuki× Kawaguchi, Hiroshi× Ito, Hiroshi× Kanno, Iwao× Tottori, Naotomo× Yamada, Yukio× Tomita, Yutaka× Itoh, Yoshiaki× Suzuki, Norihiro× Yamada, Katsuya× Masamoto, Kazuto× 村田 澪× 高田 優季× 田桑 弘之× 川口 拓之× 伊藤 浩× 菅野 巖× 鳥取 直友× 冨田 裕× 正本 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study examined glucose transfer in the cellular scale of mouse brain microvasculature in vivo using two-photon microscopy and fluorescent glucose analogue (2-NBDG). The 2-NBDG was intravenously injected (0.04 mL/min) in the anesthetized Tie2-GFP mice in which the vascular endothelium expressed fluorescent protein. Time-lapse imaging was conducted on the cortical parenchyma, while the time-intensity change of the injected 2-NBDG was analysed in respective vascular compartments (artery, capillary, and vein). We observed that 2-NBDG signal increased monotonically in the vasculature during the period of the injection, and rapidly declined following its cessation. In tissue compartment, however, the signal intensity gradually increased even after cessation of the injection. Spatiotemporal analysis of the 2-NBDG intensity over the cross-sections of the vessels further showed distinct change of the 2-NBDG intensity across the vessel wall (endothelium), which may represents a regulation site of tissue glucose influx. | |||||
| 書誌情報 |
Advances in experimental medicine and biology 巻 812, p. 241-246, 発行日 2014-04 |
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| 出版者 | ||||||
| 出版者 | Kluwer Academic/Plenum Publishers | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0065-2598 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24729239 | |||||
