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ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
https://repo.qst.go.jp/records/46932
https://repo.qst.go.jp/records/469326ef75912-da0d-4201-819a-502eba50c922
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-11-13 | |||||
タイトル | ||||||
タイトル | ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ota, Hiromitsu
× Ota, Hiromitsu× Sakurai, Masayuki× Gupta, Ravi× Valente, Louis× Wulff, Bjorn-Erik× Ariyoshi, Kentaro× Iizasa, Hisashi× V, Davuluri Ramana× Nishikura, Kazuko× et.al× 有吉 健太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein interaction. Most importantly, ADAR1 increases the maximum rate (Vmax) of pre-microRNA (miRNA) cleavage by Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes, identifying a new role of ADAR1 in miRNA processing and RNAi mechanisms. ADAR1 differentiates its functions in RNA editing and RNAi by the formation of either ADAR1/ADAR1 homodimer or Dicer/ADAR1 heterodimer complexes, respectively. As expected, the expression of miRNAs is globally inhibited in ADAR1-/- mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype. | |||||
書誌情報 |
Cell 巻 153, 号 3, p. 575-589, 発行日 2013-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0092-8674 | |||||
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識別子タイプ | URI | |||||
関連識別子 | http://www.sciencedirect.com/science/article/pii/S0092867413003462 | |||||
関連名称 | http://www.sciencedirect.com/science/article/pii/S0092867413003462 |