WEKO3
アイテム
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
https://repo.qst.go.jp/records/46932
https://repo.qst.go.jp/records/469326ef75912-da0d-4201-819a-502eba50c922
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-13 | |||||
| タイトル | ||||||
| タイトル | ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ota, Hiromitsu
× Ota, Hiromitsu× Sakurai, Masayuki× Gupta, Ravi× Valente, Louis× Wulff, Bjorn-Erik× Ariyoshi, Kentaro× Iizasa, Hisashi× V, Davuluri Ramana× Nishikura, Kazuko× et.al× 有吉 健太郎 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein interaction. Most importantly, ADAR1 increases the maximum rate (Vmax) of pre-microRNA (miRNA) cleavage by Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes, identifying a new role of ADAR1 in miRNA processing and RNAi mechanisms. ADAR1 differentiates its functions in RNA editing and RNAi by the formation of either ADAR1/ADAR1 homodimer or Dicer/ADAR1 heterodimer complexes, respectively. As expected, the expression of miRNAs is globally inhibited in ADAR1-/- mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype. | |||||
| 書誌情報 |
Cell 巻 153, 号 3, p. 575-589, 発行日 2013-04 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0092-8674 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S0092867413003462 | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S0092867413003462 | |||||
