{"created":"2023-05-15T14:36:26.802730+00:00","id":46932,"links":{},"metadata":{"_buckets":{"deposit":"e420883b-f683-4e17-8a85-437caf49f161"},"_deposit":{"created_by":1,"id":"46932","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46932"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046932","sets":["1"]},"author_link":["468372","468367","468366","468368","468374","468371","468373","468375","468369","468376","468370"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"589","bibliographicPageStart":"575","bibliographicVolumeNumber":"153","bibliographic_titles":[{"bibliographic_title":"Cell"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein interaction. Most importantly, ADAR1 increases the maximum rate (Vmax) of pre-microRNA (miRNA) cleavage by Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes, identifying a new role of ADAR1 in miRNA processing and RNAi mechanisms. ADAR1 differentiates its functions in RNA editing and RNAi by the formation of either ADAR1/ADAR1 homodimer or Dicer/ADAR1 heterodimer complexes, respectively. As expected, the expression of miRNAs is globally inhibited in ADAR1-/- mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype.","subitem_description_type":"Abstract"}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/article/pii/S0092867413003462"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S0092867413003462","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0092-8674","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ota, Hiromitsu"}],"nameIdentifiers":[{"nameIdentifier":"468366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"468367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gupta, Ravi"}],"nameIdentifiers":[{"nameIdentifier":"468368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Valente, Louis"}],"nameIdentifiers":[{"nameIdentifier":"468369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wulff, Bjorn-Erik"}],"nameIdentifiers":[{"nameIdentifier":"468370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ariyoshi, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"468371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iizasa, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"468372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"V, Davuluri Ramana"}],"nameIdentifiers":[{"nameIdentifier":"468373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikura, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"468374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"468375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"有吉 健太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468376","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-13"},"publish_date":"2014-11-13","publish_status":"0","recid":"46932","relation_version_is_last":true,"title":["ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:53.722260+00:00"}