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  1. 原著論文

Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.

https://repo.qst.go.jp/records/46889
https://repo.qst.go.jp/records/46889
b54b63e9-4dbc-4ee3-bcd7-b8d7725c84b5
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-28
タイトル
タイトル Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Shang, Yi

× Shang, Yi

WEKO 467894

Shang, Yi

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Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 467895

Kakinuma, Shizuko

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Yamauchi, Kazumi

× Yamauchi, Kazumi

WEKO 467896

Yamauchi, Kazumi

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Morioka, Takamitsu

× Morioka, Takamitsu

WEKO 467897

Morioka, Takamitsu

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Tani, Shusuke

× Tani, Shusuke

WEKO 467898

Tani, Shusuke

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Takabatake, Takashi

× Takabatake, Takashi

WEKO 467899

Takabatake, Takashi

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Kataoka, Yasushi

× Kataoka, Yasushi

WEKO 467900

Kataoka, Yasushi

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 467901

Shimada, Yoshiya

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尚 奕

× 尚 奕

WEKO 467902

en 尚 奕

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柿沼 志津子

× 柿沼 志津子

WEKO 467903

en 柿沼 志津子

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森岡 孝満

× 森岡 孝満

WEKO 467904

en 森岡 孝満

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谷 修祐

× 谷 修祐

WEKO 467905

en 谷 修祐

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高畠 貴志

× 高畠 貴志

WEKO 467906

en 高畠 貴志

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片岡 泰

× 片岡 泰

WEKO 467907

en 片岡 泰

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島田 義也

× 島田 義也

WEKO 467908

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-onset CR influences the lifetime cancer risk in mice after early-life exposure to ionizing radiation. Infant male mice (1-week-old) were exposed to 3.8 Gy X-rays, fed a control 95 kcal/week or CR 65 kcal/week diet from 7 weeks of age (adult stage), and their lifespan and tumor development were assessed. Irrespective of CR, X-rays shortened lifespan by 38%, and irrespective of irradiation CR extended lifespan by 20%. Thymic lymphoma (TL) and early-occurring non-TL were induced by radiation. The liver and Harderian gland were more susceptible to radiation-induced tumors than the lungs and non-thymic lymphoid tissues (late occurring). CR reduced the risk of hepatocellular carcinoma, late-occurring non-TL, lung tumor, Harderian tumor, and hemangioma but had less impact on TL and early-occurring non-TL. Most notably, the effects of X-rays on induction of lung tumors, late-occurring non-TL and hemangioma were essentially canceled by CR. The ability of CR to prevent late-occurring tumors was the same for non-irradiated and irradiated mice, indicating that the mechanism by which CR influences cancer is independent of irradiation. Our results indicate that adult-onset CR significantly inhibits late-occurring tumors in a tissue-dependent manner regardless of infant radiation exposure.
書誌情報 International journal of cancer. Journal international du cancer

巻 135, 号 5, p. 1038-1047, 発行日 2014-01
出版者
出版者 Wiley-Liss
ISSN
収録物識別子タイプ ISSN
収録物識別子 0020-7136
PubMed番号
識別子タイプ PMID
関連識別子 24482070
DOI
識別子タイプ DOI
関連識別子 10.1002/ijc.28751
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