{"_buckets": {"deposit": "df9ed9d0-70b2-44f6-94e3-21e47fa53bf4"}, "_deposit": {"created_by": 1, "id": "46889", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46889"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046889", "sets": ["1"]}, "author_link": ["467900", "467898", "467903", "467907", "467895", "467902", "467904", "467908", "467901", "467905", "467899", "467897", "467894", "467906", "467896"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "1047", "bibliographicPageStart": "1038", "bibliographicVolumeNumber": "135", "bibliographic_titles": [{"bibliographic_title": "International journal of cancer. Journal international du cancer"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-onset CR influences the lifetime cancer risk in mice after early-life exposure to ionizing radiation. Infant male mice (1-week-old) were exposed to 3.8 Gy X-rays, fed a control 95 kcal/week or CR 65 kcal/week diet from 7 weeks of age (adult stage), and their lifespan and tumor development were assessed. Irrespective of CR, X-rays shortened lifespan by 38%, and irrespective of irradiation CR extended lifespan by 20%. Thymic lymphoma (TL) and early-occurring non-TL were induced by radiation. The liver and Harderian gland were more susceptible to radiation-induced tumors than the lungs and non-thymic lymphoid tissues (late occurring). CR reduced the risk of hepatocellular carcinoma, late-occurring non-TL, lung tumor, Harderian tumor, and hemangioma but had less impact on TL and early-occurring non-TL. Most notably, the effects of X-rays on induction of lung tumors, late-occurring non-TL and hemangioma were essentially canceled by CR. The ability of CR to prevent late-occurring tumors was the same for non-irradiated and irradiated mice, indicating that the mechanism by which CR influences cancer is independent of irradiation. Our results indicate that adult-onset CR significantly inhibits late-occurring tumors in a tissue-dependent manner regardless of infant radiation exposure.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley-Liss"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "24482070", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/ijc.28751", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0020-7136", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shang, Yi"}], "nameIdentifiers": [{"nameIdentifier": "467894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kakinuma, Shizuko"}], "nameIdentifiers": [{"nameIdentifier": "467895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamauchi, Kazumi"}], "nameIdentifiers": [{"nameIdentifier": "467896", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morioka, Takamitsu"}], "nameIdentifiers": [{"nameIdentifier": "467897", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tani, Shusuke"}], "nameIdentifiers": [{"nameIdentifier": "467898", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takabatake, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "467899", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kataoka, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "467900", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Yoshiya"}], "nameIdentifiers": [{"nameIdentifier": "467901", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "尚 奕", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467902", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柿沼 志津子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467903", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森岡 孝満", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467904", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "谷 修祐", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467905", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畠 貴志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467906", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "片岡 泰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467907", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田 義也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "467908", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46889", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-10-28"}, "publish_date": "2014-10-28", "publish_status": "0", "recid": "46889", "relation": {}, "relation_version_is_last": true, "title": ["Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice."], "weko_shared_id": -1}