{"created":"2023-05-15T14:36:24.899716+00:00","id":46889,"links":{},"metadata":{"_buckets":{"deposit":"df9ed9d0-70b2-44f6-94e3-21e47fa53bf4"},"_deposit":{"created_by":1,"id":"46889","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46889"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046889","sets":["1"]},"author_link":["467900","467898","467903","467907","467895","467902","467904","467908","467901","467905","467899","467897","467894","467906","467896"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1047","bibliographicPageStart":"1038","bibliographicVolumeNumber":"135","bibliographic_titles":[{"bibliographic_title":"International journal of cancer. Journal international du cancer"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-onset CR influences the lifetime cancer risk in mice after early-life exposure to ionizing radiation. Infant male mice (1-week-old) were exposed to 3.8 Gy X-rays, fed a control 95 kcal/week or CR 65 kcal/week diet from 7 weeks of age (adult stage), and their lifespan and tumor development were assessed. Irrespective of CR, X-rays shortened lifespan by 38%, and irrespective of irradiation CR extended lifespan by 20%. Thymic lymphoma (TL) and early-occurring non-TL were induced by radiation. The liver and Harderian gland were more susceptible to radiation-induced tumors than the lungs and non-thymic lymphoid tissues (late occurring). CR reduced the risk of hepatocellular carcinoma, late-occurring non-TL, lung tumor, Harderian tumor, and hemangioma but had less impact on TL and early-occurring non-TL. Most notably, the effects of X-rays on induction of lung tumors, late-occurring non-TL and hemangioma were essentially canceled by CR. The ability of CR to prevent late-occurring tumors was the same for non-irradiated and irradiated mice, indicating that the mechanism by which CR influences cancer is independent of irradiation. Our results indicate that adult-onset CR significantly inhibits late-occurring tumors in a tissue-dependent manner regardless of infant radiation exposure.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-Liss"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24482070","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/ijc.28751","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0020-7136","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"467894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"467895","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Kazumi"}],"nameIdentifiers":[{"nameIdentifier":"467896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morioka, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"467897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tani, Shusuke"}],"nameIdentifiers":[{"nameIdentifier":"467898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takabatake, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"467899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"467900","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"467901","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467902","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467903","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森岡 孝満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷 修祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畠 貴志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"片岡 泰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467908","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-28"},"publish_date":"2014-10-28","publish_status":"0","recid":"46889","relation_version_is_last":true,"title":["Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:46:24.814956+00:00"}