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Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy.
https://repo.qst.go.jp/records/46888
https://repo.qst.go.jp/records/46888509163c1-629a-423f-9e2b-25f770689bed
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-22 | |||||
| タイトル | ||||||
| タイトル | Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tajima, Yosuke
× Tajima, Yosuke× Takuwa, Hiroyuki× Kokuryo, Daisuke× Kawaguchi, Hiroshi× Seki, Chie× Masamoto, Kazuto× Ikoma, Yoko× Taniguchi, Junko× Aoki, Ichio× Tomita, Yutaka× Suzuki, Norihiro× Kanno, Iwao× Saeki, Naokatsu× Ito, Hiroshi× 田島 洋佑× 田桑 弘之× 國領 大介× 川口 拓之× 関 千江× 正本 和人× 生駒 洋子× 谷口 順子× 青木 伊知男× 冨田 裕× 菅野 巖× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aimed to examine the cortical microvessel diameter response to hypercapnia in misery perfusion using two-photon laser scanning microscopy (TPLSM). We evaluated whether the vascular response to hypercapnia could represent the cerebrovascular reserve. Cerebral blood flow (CBF) during normocapnia and hypercapnia was measured by laser-Doppler flowmetry through cranial windows in awake C57/BL6 mice before and at 1, 7, 14, and 28 days after unilateral common carotid artery occlusion (UCCAO). Diameters of the cortical microvessels during normocapnia and hypercapnia were also measured by TPLSM. Cerebral blood flow and the vascular response to hypercapnia were decreased after UCCAO. Before UCCAO, vasodilation during hypercapnia was found primarily in arterioles (22.9%±3.5%). At 14 days after UCCAO, arterioles, capillaries, and venules were autoregulatorily dilated by 79.5%±19.7%, 57.2%±32.3%, and 32.0%±10.8%, respectively. At the same time, the diameter response to hypercapnia in arterioles was significantly decreased to 1.9%±1.5%. A significant negative correlation was observed between autoregulatory vasodilation and the diameter response to hypercapnia in arterioles. Our findings indicate that arterioles play main roles in both autoregulatory vasodilation and hypercapnic vasodilation, and that the vascular response to hypercapnia can be used to estimate the cerebrovascular reserve.Journal of Cerebral Blood Flow & Metabolism advance online publication, 21 May 2014; doi:10.1038/jcbfm.2014.91. | |||||
| 書誌情報 |
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 巻 34, p. 1363-1372, 発行日 2014-05 |
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| 出版者 | ||||||
| 出版者 | Nature Pub. Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0271-678X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24849667 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/jcbfm.2014.91 | |||||
