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Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice
https://repo.qst.go.jp/records/46854
https://repo.qst.go.jp/records/4685469056a83-13f1-4a3a-abd8-7c318db09860
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-20 | |||||
| タイトル | ||||||
| タイトル | Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ariyoshi, Kentaro
× Ariyoshi, Kentaro× Takabatake, Takashi× Shinagawa, Mayumi× Kadono, Kyoko× Daino, Kazuhiro× Imaoka, Tatsuhiko× Kakinuma, Shizuko× Nishimura, Mayumi× Shimada, Yoshiya× 有吉 健太郎× 高畠 貴志× 品川 まゆみ× 角野 響子× 臺野 和広× 今岡 達彦× 柿沼 志津子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Age at exposure is a critical factor that influences the risk of radiation-induced leukemia, which arises from hematopoietic stem cells. However, little is known about the effect of age on the radiation response in these cells. Here we examined the radiation response of hematopoietic stem and progenitor cells in infant (1 week old), juvenile (3 weeks), and adult (8 and 14 weeks) C3H/He mice, which are susceptible to radiation induction of myeloid leukemia. We first demonstrated that infant cells were the most susceptible to radiation-induced cell killing. However, in vitro irradiation of these cells showed no age differences, suggesting that radiation sensitivity is ascribed to the bone marrow microenvironment rather than to the intrinsic nature of progenitors themselves. Expression profiles of bone marrow tissues revealed that radioprotective chemokine and cytokine expression was dependent on age at exposure and time after irradiation. There was no difference, however, in the basal expression of these factors among age groups. In contrast, radiation induction of Csf2 and Fgf1 was evident in adult tissues, but not in infant tissues. These results suggest that the decreased survival of hematopoietic stem and progenitor cells in irradiated infant mice may be attributed to a failure to induce a subset of radioprotective cytokines in the bone marrow microenvironment. | |||||
| 書誌情報 |
Radiation Research 巻 181, 号 3, p. 302-313, 発行日 2014-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
