@article{oai:repo.qst.go.jp:00046854,
 author = {Ariyoshi, Kentaro and Takabatake, Takashi and Shinagawa, Mayumi and Kadono, Kyoko and Daino, Kazuhiro and Imaoka, Tatsuhiko and Kakinuma, Shizuko and Nishimura, Mayumi and Shimada, Yoshiya and 有吉 健太郎 and 高畠 貴志 and 品川 まゆみ and 角野 響子 and 臺野 和広 and 今岡 達彦 and 柿沼 志津子 and 西村 まゆみ and 島田 義也},
 issue = {3},
 journal = {Radiation Research},
 month = {Mar},
 note = {Age at exposure is a critical factor that influences the risk of radiation-induced leukemia, which arises from hematopoietic stem cells. However, little is known about the effect of age on the radiation response in these cells. Here we examined the radiation response of hematopoietic stem and progenitor cells in infant (1 week old), juvenile (3 weeks), and adult (8 and 14 weeks) C3H/He mice, which are susceptible to radiation induction of myeloid leukemia. We first demonstrated that infant cells were the most susceptible to radiation-induced cell killing. However, in vitro irradiation of these cells showed no age differences, suggesting that radiation sensitivity is ascribed to the bone marrow microenvironment rather than to the intrinsic nature of progenitors themselves. Expression profiles of bone marrow tissues revealed that radioprotective chemokine and cytokine expression was dependent on age at exposure and time after irradiation. There was no difference, however, in the basal expression of these factors among age groups. In contrast, radiation induction of Csf2 and Fgf1 was evident in adult tissues, but not in infant tissues. These results suggest that the decreased survival of hematopoietic stem and progenitor cells in irradiated infant mice may be attributed to a failure to induce a subset of radioprotective cytokines in the bone marrow microenvironment.},
 pages = {302--313},
 title = {Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice},
 volume = {181},
 year = {2014}
}