WEKO3
アイテム
Role of Autophagy in High-LET Radiation-induced Cytotoxicity to Tumor Cells.
https://repo.qst.go.jp/records/46800
https://repo.qst.go.jp/records/4680013ec0ec6-405b-4289-ad9b-c08842c1db3a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-30 | |||||
| タイトル | ||||||
| タイトル | Role of Autophagy in High-LET Radiation-induced Cytotoxicity to Tumor Cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Jin, Xiaodong
× Jin, Xiaodong× Liu, Yan× Ye, Fei× Liu, Xiongxiong× Furusawa, Yoshiya× Wu, Qingfeng× Li, Feifei× Zheng, Xiaogang× Dai, Zhongying× Li, Qiang× Ｊｉｎ Ｘｉａｏｄｏｎｇ× Ｌｉｕ Ｙａｎ× Ｙｅ Ｆｅｉ× 古澤 佳也× Ｗｕ Ｑｉｎｇｆｅｎｇ× Ｄａｉ Ｚｈｏｎｇｙｉｎｇ× 李 強 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heavy-ion radiotherapy has a potential advantage over conventional radiotherapy due to improved dose distribution and a higher biological effectiveness in cancer therapy. However, there is a little information currently available on the cellular and molecular basis for heavy-ion irradiation induced cell death. Recently, autophagy as a novel important target to improve anticancer therapy attracts considerable attention. In this study, the effect of autophagy induced by high linear energy transfer (LET) carbon ions was examined in various tumor cell lines. To our knowledge, our study is the first time to reveal that high-LET carbon ions could induce autophagy in various tumor cells effectively and the autophagic level in the irradiated cells increased in a dose- and LET-dependent manner. The ability of carbon ions to inhibit the activation of the PI3K/Akt pathway rose with increasing their LET. Moreover, modulation of autophagy in tumor cells could modify their sensitivity to high-LET radiation and inhibiting autophagy accelerated apoptotic cell death definitely, resulting in an increase in radiosensitivity. Our data imply that targeting autophagy might enhance the effectiveness of heavy ion radiotherapy. This article is protected by copyright. All rights reserved. | |||||
| 書誌情報 |
Cancer Science 巻 105, 号 7, p. 770-778, 発行日 2014-04 |
|||||
| 出版者 | ||||||
| 出版者 | WILEY | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-9032 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24731006 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/cas.12422 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://onlinelibrary.wiley.com/doi/10.1111/cas.12422/abstract;jsessionid=EFD2FE1D895592CD6EC3F2557CDEDC5C.f01t04 | |||||
| 関連名称 | http://onlinelibrary.wiley.com/doi/10.1111/cas.12422/abstract;jsessionid=EFD2FE1D895592CD6EC3F2557CDEDC5C.f01t04 | |||||
