{"created":"2023-05-15T14:36:20.962968+00:00","id":46800,"links":{},"metadata":{"_buckets":{"deposit":"4a6679e8-558c-4d1a-9ddf-938b900b3773"},"_deposit":{"created_by":1,"id":"46800","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46800"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046800","sets":["1"]},"author_link":["466822","466825","466827","466823","466820","466831","466830","466824","466819","466829","466828","466835","466826","466821","466832","466833","466834"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"778","bibliographicPageStart":"770","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Heavy-ion radiotherapy has a potential advantage over conventional radiotherapy due to improved dose distribution and a higher biological effectiveness in cancer therapy. However, there is a little information currently available on the cellular and molecular basis for heavy-ion irradiation induced cell death. Recently, autophagy as a novel important target to improve anticancer therapy attracts considerable attention. In this study, the effect of autophagy induced by high linear energy transfer (LET) carbon ions was examined in various tumor cell lines. To our knowledge, our study is the first time to reveal that high-LET carbon ions could induce autophagy in various tumor cells effectively and the autophagic level in the irradiated cells increased in a dose- and LET-dependent manner. The ability of carbon ions to inhibit the activation of the PI3K/Akt pathway rose with increasing their LET. Moreover, modulation of autophagy in tumor cells could modify their sensitivity to high-LET radiation and inhibiting autophagy accelerated apoptotic cell death definitely, resulting in an increase in radiosensitivity. Our data imply that targeting autophagy might enhance the effectiveness of heavy ion radiotherapy. This article is protected by copyright. All rights reserved.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24731006","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.12422","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://onlinelibrary.wiley.com/doi/10.1111/cas.12422/abstract;jsessionid=EFD2FE1D895592CD6EC3F2557CDEDC5C.f01t04"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://onlinelibrary.wiley.com/doi/10.1111/cas.12422/abstract;jsessionid=EFD2FE1D895592CD6EC3F2557CDEDC5C.f01t04","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jin, Xiaodong"}],"nameIdentifiers":[{"nameIdentifier":"466819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Yan"}],"nameIdentifiers":[{"nameIdentifier":"466820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ye, Fei"}],"nameIdentifiers":[{"nameIdentifier":"466821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Xiongxiong"}],"nameIdentifiers":[{"nameIdentifier":"466822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"466823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wu, Qingfeng"}],"nameIdentifiers":[{"nameIdentifier":"466824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Feifei"}],"nameIdentifiers":[{"nameIdentifier":"466825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zheng, Xiaogang"}],"nameIdentifiers":[{"nameIdentifier":"466826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dai, Zhongying"}],"nameIdentifiers":[{"nameIdentifier":"466827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Qiang"}],"nameIdentifiers":[{"nameIdentifier":"466828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｊｉｎ Ｘｉａｏｄｏｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｌｉｕ Ｙａｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｙｅ Ｆｅｉ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｗｕ Ｑｉｎｇｆｅｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｄａｉ Ｚｈｏｎｇｙｉｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"李 強","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466835","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of Autophagy in High-LET Radiation-induced Cytotoxicity to Tumor Cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of Autophagy in High-LET Radiation-induced Cytotoxicity to Tumor Cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-30"},"publish_date":"2014-07-30","publish_status":"0","recid":"46800","relation_version_is_last":true,"title":["Role of Autophagy in High-LET Radiation-induced Cytotoxicity to Tumor Cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:47:28.350711+00:00"}