{"_buckets": {"deposit": "e6f5423e-8dc7-4ceb-a2b0-92cd3d83ef1e"}, "_deposit": {"created_by": 1, "id": "46788", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46788"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046788", "sets": ["1"]}, "author_link": ["466672", "466669", "466666", "466675", "466673", "466676", "466679", "466680", "466682", "466681", "466677", "466668", "466683", "466674", "466667", "466671", "466678", "466670", "466665"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "402", "bibliographicPageStart": "395", "bibliographicVolumeNumber": "16", "bibliographic_titles": [{"bibliographic_title": "Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Rho is a small molecular weight GTP-binding protein and works as a molecular shuttling switch between an active (GTP-bound) and inactive (GDP-bound) state. Rho is known to be involved in cell motility, cell adhesion, and cytokinesis through actin cytoskeleton reorganization. The GTP-bound form of Rho interacts with its specific downstream target, triggering intracellular signaling cascades. Rho effectors such as Rho-kinases have been isolated on the basis of their selective binding to the GTP-bound form of Rho. Rho-kinase is thought to have an important role in the pathogenesis of a variety of neurological diseases because activation of the Rho/Rho-kinase pathway has been observed in various central nervous system disorders. Previous histochemical studies have shown multiple molecular mechanisms for the regulation of Rho-kinase. Neuroimaging of Rho/Rho-kinase has rarely been studied because of a lack of appropriate radiotracers. Recently, N-[(11)C]methyl-hydroxyfasudil, a new radiotracer for positron emission tomography (PET), has been introduced to measure Rho-kinase activity. In this study, the regional distribution and kinetics of N-[(11)C]methyl-hydroxyfasudil were investigated in the brains of mice.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "24155033", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s11307-013-0695-y", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1536-1632", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Taniguchi, Junko"}], "nameIdentifiers": [{"nameIdentifier": "466665", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie"}], "nameIdentifiers": [{"nameIdentifier": "466666", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takuwa, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "466667", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawaguchi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "466668", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikoma, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "466669", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "466670", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanno, Iwao"}], "nameIdentifiers": [{"nameIdentifier": "466671", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "466672", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwabara, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "466673", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "466674", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "谷口 順子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "関 千江", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田桑 弘之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "川口 拓之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466678", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "生駒 洋子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466679", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤永 雅之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466680", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菅野 巖", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466681", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466682", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤 浩", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "466683", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46788", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-07-22"}, "publish_date": "2014-07-22", "publish_status": "0", "recid": "46788", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography."], "weko_shared_id": -1}