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Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography.
https://repo.qst.go.jp/records/46788
https://repo.qst.go.jp/records/467887464d651-14d1-4f0b-affd-0a45efd57e62
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-22 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Taniguchi, Junko
× Taniguchi, Junko× Seki, Chie× Takuwa, Hiroyuki× Kawaguchi, Hiroshi× Ikoma, Yoko× Fujinaga, Masayuki× Kanno, Iwao× Zhang, Ming-Rong× Kuwabara, Satoshi× Ito, Hiroshi× 谷口 順子× 関 千江× 田桑 弘之× 川口 拓之× 生駒 洋子× 藤永 雅之× 菅野 巖× 張 明栄× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Rho is a small molecular weight GTP-binding protein and works as a molecular shuttling switch between an active (GTP-bound) and inactive (GDP-bound) state. Rho is known to be involved in cell motility, cell adhesion, and cytokinesis through actin cytoskeleton reorganization. The GTP-bound form of Rho interacts with its specific downstream target, triggering intracellular signaling cascades. Rho effectors such as Rho-kinases have been isolated on the basis of their selective binding to the GTP-bound form of Rho. Rho-kinase is thought to have an important role in the pathogenesis of a variety of neurological diseases because activation of the Rho/Rho-kinase pathway has been observed in various central nervous system disorders. Previous histochemical studies have shown multiple molecular mechanisms for the regulation of Rho-kinase. Neuroimaging of Rho/Rho-kinase has rarely been studied because of a lack of appropriate radiotracers. Recently, N-[(11)C]methyl-hydroxyfasudil, a new radiotracer for positron emission tomography (PET), has been introduced to measure Rho-kinase activity. In this study, the regional distribution and kinetics of N-[(11)C]methyl-hydroxyfasudil were investigated in the brains of mice. | |||||
| 書誌情報 |
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 巻 16, 号 3, p. 395-402, 発行日 2013-10 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1536-1632 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24155033 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11307-013-0695-y | |||||
