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  1. 原著論文

Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography.

https://repo.qst.go.jp/records/46788
https://repo.qst.go.jp/records/46788
7464d651-14d1-4f0b-affd-0a45efd57e62
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-22
タイトル
タイトル Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Taniguchi, Junko

× Taniguchi, Junko

WEKO 466665

Taniguchi, Junko

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Seki, Chie

× Seki, Chie

WEKO 466666

Seki, Chie

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Takuwa, Hiroyuki

× Takuwa, Hiroyuki

WEKO 466667

Takuwa, Hiroyuki

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Kawaguchi, Hiroshi

× Kawaguchi, Hiroshi

WEKO 466668

Kawaguchi, Hiroshi

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Ikoma, Yoko

× Ikoma, Yoko

WEKO 466669

Ikoma, Yoko

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Fujinaga, Masayuki

× Fujinaga, Masayuki

WEKO 466670

Fujinaga, Masayuki

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Kanno, Iwao

× Kanno, Iwao

WEKO 466671

Kanno, Iwao

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 466672

Zhang, Ming-Rong

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Kuwabara, Satoshi

× Kuwabara, Satoshi

WEKO 466673

Kuwabara, Satoshi

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Ito, Hiroshi

× Ito, Hiroshi

WEKO 466674

Ito, Hiroshi

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谷口 順子

× 谷口 順子

WEKO 466675

en 谷口 順子

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関 千江

× 関 千江

WEKO 466676

en 関 千江

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田桑 弘之

× 田桑 弘之

WEKO 466677

en 田桑 弘之

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川口 拓之

× 川口 拓之

WEKO 466678

en 川口 拓之

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生駒 洋子

× 生駒 洋子

WEKO 466679

en 生駒 洋子

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藤永 雅之

× 藤永 雅之

WEKO 466680

en 藤永 雅之

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菅野 巖

× 菅野 巖

WEKO 466681

en 菅野 巖

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張 明栄

× 張 明栄

WEKO 466682

en 張 明栄

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伊藤 浩

× 伊藤 浩

WEKO 466683

en 伊藤 浩

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抄録
内容記述タイプ Abstract
内容記述 Rho is a small molecular weight GTP-binding protein and works as a molecular shuttling switch between an active (GTP-bound) and inactive (GDP-bound) state. Rho is known to be involved in cell motility, cell adhesion, and cytokinesis through actin cytoskeleton reorganization. The GTP-bound form of Rho interacts with its specific downstream target, triggering intracellular signaling cascades. Rho effectors such as Rho-kinases have been isolated on the basis of their selective binding to the GTP-bound form of Rho. Rho-kinase is thought to have an important role in the pathogenesis of a variety of neurological diseases because activation of the Rho/Rho-kinase pathway has been observed in various central nervous system disorders. Previous histochemical studies have shown multiple molecular mechanisms for the regulation of Rho-kinase. Neuroimaging of Rho/Rho-kinase has rarely been studied because of a lack of appropriate radiotracers. Recently, N-[(11)C]methyl-hydroxyfasudil, a new radiotracer for positron emission tomography (PET), has been introduced to measure Rho-kinase activity. In this study, the regional distribution and kinetics of N-[(11)C]methyl-hydroxyfasudil were investigated in the brains of mice.
書誌情報 Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

巻 16, 号 3, p. 395-402, 発行日 2013-10
出版者
出版者 Springer
ISSN
収録物識別子タイプ ISSN
収録物識別子 1536-1632
PubMed番号
識別子タイプ PMID
関連識別子 24155033
DOI
識別子タイプ DOI
関連識別子 10.1007/s11307-013-0695-y
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