@article{oai:repo.qst.go.jp:00046788,
 author = {Taniguchi, Junko and Seki, Chie and Takuwa, Hiroyuki and Kawaguchi, Hiroshi and Ikoma, Yoko and Fujinaga, Masayuki and Kanno, Iwao and Zhang, Ming-Rong and Kuwabara, Satoshi and Ito, Hiroshi and 谷口 順子 and 関 千江 and 田桑 弘之 and 川口 拓之 and 生駒 洋子 and 藤永 雅之 and 菅野 巖 and 張 明栄 and 伊藤 浩},
 issue = {3},
 journal = {Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging},
 month = {Oct},
 note = {Rho is a small molecular weight GTP-binding protein and works as a molecular shuttling switch between an active (GTP-bound) and inactive (GDP-bound) state. Rho is known to be involved in cell motility, cell adhesion, and cytokinesis through actin cytoskeleton reorganization. The GTP-bound form of Rho interacts with its specific downstream target, triggering intracellular signaling cascades. Rho effectors such as Rho-kinases have been isolated on the basis of their selective binding to the GTP-bound form of Rho. Rho-kinase is thought to have an important role in the pathogenesis of a variety of neurological diseases because activation of the Rho/Rho-kinase pathway has been observed in various central nervous system disorders. Previous histochemical studies have shown multiple molecular mechanisms for the regulation of Rho-kinase. Neuroimaging of Rho/Rho-kinase has rarely been studied because of a lack of appropriate radiotracers. Recently, N-[(11)C]methyl-hydroxyfasudil, a new radiotracer for positron emission tomography (PET), has been introduced to measure Rho-kinase activity. In this study, the regional distribution and kinetics of N-[(11)C]methyl-hydroxyfasudil were investigated in the brains of mice.},
 pages = {395--402},
 title = {Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography.},
 volume = {16},
 year = {2013}
}