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A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells.
https://repo.qst.go.jp/records/46768
https://repo.qst.go.jp/records/46768270721f3-cfe5-4072-845f-f452cdbd20e1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-27 | |||||
| タイトル | ||||||
| タイトル | A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Gao, Jianchao
× Gao, Jianchao× Aslam, Khan Ammad× Shimokawa, Takashi× Zhan, Jun× Strömblad, Staffan× Fang, Weigang× Zhang, Hongquan× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Kindlin-2 is engaged in tumor progression. However, the mechanism accounting for Kindlin-2 regulation in tumor cells remained largely unknown. Here, we report a regulatory loop between Kindlin-2 and GLI1, an effector of Hedgehog signaling pathway. We show that Kindlin-2 is transcriptionally downregulated via GLI1 occupancy on the Kindlin-2 promoter. Adversely, we found that Kindlin-2 promotes GLI1 expression through a mechanism involving GSK3β inactivation and is independent of Smoothened. Functionally, knockdown of Kindlin-2 cooperates with cyclopamine, a Smoothened antagonist, to decrease the viability of prostate cancer cells. Taken together, targeting the Kindlin-2-GLI1 feedback loop may facilitate the killing of prostate cancer cells. | |||||
| 書誌情報 |
FEBS letters 巻 587, 号 6, p. 631-8, 発行日 2013-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier Science B.V | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0014-5793 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 23337877 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.febslet.2012.12.028 | |||||
