{"created":"2023-05-15T14:36:19.563119+00:00","id":46768,"links":{},"metadata":{"_buckets":{"deposit":"c5c1e324-fcee-4a11-afe1-7f1e8062eb70"},"_deposit":{"created_by":1,"id":"46768","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46768"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046768","sets":["1"]},"author_link":["466447","466445","466442","466448","466441","466444","466446","466443"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"631-8","bibliographicVolumeNumber":"587","bibliographic_titles":[{"bibliographic_title":"FEBS letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Kindlin-2 is engaged in tumor progression. However, the mechanism accounting for Kindlin-2 regulation in tumor cells remained largely unknown. Here, we report a regulatory loop between Kindlin-2 and GLI1, an effector of Hedgehog signaling pathway. We show that Kindlin-2 is transcriptionally downregulated via GLI1 occupancy on the Kindlin-2 promoter. Adversely, we found that Kindlin-2 promotes GLI1 expression through a mechanism involving GSK3β inactivation and is independent of Smoothened. Functionally, knockdown of Kindlin-2 cooperates with cyclopamine, a Smoothened antagonist, to decrease the viability of prostate cancer cells. Taken together, targeting the Kindlin-2-GLI1 feedback loop may facilitate the killing of prostate cancer cells.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Science B.V"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23337877","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.febslet.2012.12.028","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-5793","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Gao, Jianchao"}],"nameIdentifiers":[{"nameIdentifier":"466441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aslam, Khan Ammad"}],"nameIdentifiers":[{"nameIdentifier":"466442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"466443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhan, Jun"}],"nameIdentifiers":[{"nameIdentifier":"466444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Strömblad, Staffan"}],"nameIdentifiers":[{"nameIdentifier":"466445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fang, Weigang"}],"nameIdentifiers":[{"nameIdentifier":"466446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Hongquan"}],"nameIdentifiers":[{"nameIdentifier":"466447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466448","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-27"},"publish_date":"2014-06-27","publish_status":"0","recid":"46768","relation_version_is_last":true,"title":["A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:47:49.778601+00:00"}