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OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain.
https://repo.qst.go.jp/records/46752
https://repo.qst.go.jp/records/467524ee63e33-971d-4063-84c1-9d1eb8668697
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-13 | |||||
| タイトル | ||||||
| タイトル | OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kikuchi, Tatsuya
× Kikuchi, Tatsuya× Okamura, Toshimitsu× Wakizaka, Hidekatsu× Okada, Maki× Odaka, Kenichi× Yui, Joji× B, Tsuji Atsushi× Fukumura, Toshimitsu× Zhang, Ming-Rong× 菊池 達矢× 岡村 敏充× 脇坂 秀克× 岡田 真希× 小高 謙一× 由井 譲二× 辻 厚至× 福村 利光× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | After administration of the (99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ((99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed at the blood-brain barrier in mice, in this species difference. The efflux rate of radioactivity in the cerebrum of Oat3(-/-) mice at later phase was 20% of that of control mice. Thus, organic anion transporters in mouse brain would be involved in the low brain retention of radioactivity after (99m)Tc-ECD administration. | |||||
| 書誌情報 |
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 巻 34, 号 4, p. 585-588, 発行日 2014-01 |
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| 出版者 | ||||||
| 出版者 | Nature Pub. Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0271-678X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24496177 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/jcbfm.2014.20 | |||||
