@article{oai:repo.qst.go.jp:00046752,
 author = {Kikuchi, Tatsuya and Okamura, Toshimitsu and Wakizaka, Hidekatsu and Okada, Maki and Odaka, Kenichi and Yui, Joji and B, Tsuji Atsushi and Fukumura, Toshimitsu and Zhang, Ming-Rong and 菊池 達矢 and 岡村 敏充 and 脇坂 秀克 and 岡田 真希 and 小高 謙一 and 由井 譲二 and 辻 厚至 and 福村 利光 and 張 明栄},
 issue = {4},
 journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
 month = {Jan},
 note = {After administration of the (99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ((99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed at the blood-brain barrier in mice, in this species difference. The efflux rate of radioactivity in the cerebrum of Oat3(-/-) mice at later phase was 20% of that of control mice. Thus, organic anion transporters in mouse brain would be involved in the low brain retention of radioactivity after (99m)Tc-ECD administration.},
 pages = {585--588},
 title = {OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain.},
 volume = {34},
 year = {2014}
}