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In Vivo Identification of Sentinel Lymph Nodes Using MRI and Size-Controlled and Monodispersed Magnetite Nanoparticles
https://repo.qst.go.jp/records/46686
https://repo.qst.go.jp/records/466868aea71c3-d289-4d62-91a8-10a0720b7c74
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-16 | |||||
| タイトル | ||||||
| タイトル | In Vivo Identification of Sentinel Lymph Nodes Using MRI and Size-Controlled and Monodispersed Magnetite Nanoparticles | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iida, Shuji
× Iida, Shuji× Imai, Kensuke× Matsuda, Sachiko× Kokuryo, Daisuke× Aoki, Ichio× et.al× 國領 大介× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To develop a sentinel lymph node (SN) identification method using accurately synthesized magnetic nanoparticles (MNPs), as an enhanced specific SN tracer in combination with magnetic resonance imaging (MRI) in intact rodent and SN metastasis models. Materials and Methods: Three sizes of MNPs were originally synthesized. We developed an experimental rat SN model, with brachial lymph nodes (Br) as the SN and the axillary lymph node (Ax) as the second lymph node, and injection of MNPs via the front paw. SN detectability was evaluated in vivo using T1-weighted MR images after injection of the synthesized MNPs, and the amount of iron in the Br and in the Ax was assessed using inductively coupled plasma optical emission spectrometry. Results: The highest ratios of the amount of iron in the Br versus the Ax were 3.1 and 3.3, using 20-nm MNPs after 2- and 24-hour injections. The appropriate dose and particle diameter for MRI detection was optimized, and the SN was optimally distinguished in the normal and metastatic rat models using MRI after a 0.4 mg/kg 20-nm MNP injection. Conclusion: We developed and optimized a useful S Nidentification method using MRI in rodent models. |
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| 書誌情報 |
Journal of Magnetic Resonance Imaging : JMRI 巻 38, 号 6, p. 1346-1355, 発行日 2013-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-1807 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jmri.24108.{epub ahead of print] | |||||
