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Evaluation of the Comet Assay for Assessing the Dose-Response Relationship of DNA Damage Induced by Ionizing Radiation.
https://repo.qst.go.jp/records/46666
https://repo.qst.go.jp/records/4666643ad2020-d57c-47d9-82d9-204f56b6e729
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-11 | |||||
| タイトル | ||||||
| タイトル | Evaluation of the Comet Assay for Assessing the Dose-Response Relationship of DNA Damage Induced by Ionizing Radiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yan, Wang（王 彦）
× Yan, Wang（王 彦）× Chang, Xu（徐 暢）× Li, Qing Du（杜 利清）× Jia, Cao （曹 佳）× Jian, Xiang Liu（劉 建香）× Xu, Su（蘇 旭）× Hui, Zhao（趙 輝）× Fei-Yue, Fan（樊 飛躍）× Wang, Bing× Katube, Takanori× Sai, Jun Fan（樊 賽軍）× Qiang, Liu（劉 強）× 王 冰× 勝部 孝則 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dose- and time-response curves were combined to assess the potential of the comet assay in radiation biodosimetry. The neutral comet assay was used to detect DNA double-strand breaks in lymphocytes caused by γ-ray irradiation. A clear dose-response relationship with DNA double-strand breaks using the comet assay was found at different times after irradiation (p < 0.001). A time-response relationship was also found within 72 h after irradiation (p < 0.001). The curves for DNA double-strand breaks and DNA repair in vitro of human lymphocytes presented a nice model, and a smooth, three-dimensional plane model was obtained when the two curves were combined. | |||||
| 書誌情報 |
International Journal of Molecular Sciences. 巻 14, 号 11, p. 22449-22461, 発行日 2013-11 |
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