@article{oai:repo.qst.go.jp:00046666, author = {Yan, Wang(王 彦) and Chang, Xu(徐 暢) and Li, Qing Du(杜 利清) and Jia, Cao (曹 佳) and Jian, Xiang Liu(劉 建香) and Xu, Su(蘇 旭) and Hui, Zhao(趙 輝) and Fei-Yue, Fan(樊 飛躍) and Wang, Bing and Katube, Takanori and Sai, Jun Fan(樊 賽軍) and Qiang, Liu(劉 強) and 王 冰 and 勝部 孝則}, issue = {11}, journal = {International Journal of Molecular Sciences.}, month = {Nov}, note = {Dose- and time-response curves were combined to assess the potential of the comet assay in radiation biodosimetry. The neutral comet assay was used to detect DNA double-strand breaks in lymphocytes caused by γ-ray irradiation. A clear dose-response relationship with DNA double-strand breaks using the comet assay was found at different times after irradiation (p < 0.001). A time-response relationship was also found within 72 h after irradiation (p < 0.001). The curves for DNA double-strand breaks and DNA repair in vitro of human lymphocytes presented a nice model, and a smooth, three-dimensional plane model was obtained when the two curves were combined.}, pages = {22449--22461}, title = {Evaluation of the Comet Assay for Assessing the Dose-Response Relationship of DNA Damage Induced by Ionizing Radiation.}, volume = {14}, year = {2013} }