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Interferon-b delivery via human neural stem cell abates glial scar formation in spinal cord injury
https://repo.qst.go.jp/records/46655
https://repo.qst.go.jp/records/466553ee17fdc-431b-4012-b600-8a88bf49394a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-02 | |||||
| タイトル | ||||||
| タイトル | Interferon-b delivery via human neural stem cell abates glial scar formation in spinal cord injury | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishimura, Yusuke
× Nishimura, Yusuke× Aoki, Ichio× Saga, Tsuneo× et.al× 青木 伊知男× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Glial scar formation is the major impedence to axonal regrowth after spinal cord injury (SCI), and scar-modulating treatments have become a leading therapeutic goal for SCI treatment. In this study human neural stem cells (NSCs) encoding interferon (IFN)-b gene were administered intravenously to mice 1 week after spinal cord injury. Animals receiving NSCs encoding IFN-b exhibited significant neurobehavioral improvement, electrophysiological recovery, suppressed glial scar formation and preservation of nerve fibers in lesioned spinal cord. Systemic evaluation of SCI gliosis lesion site with lesion-specific microdissection, genomewide microarray and MetaCore pathway analysis identified upregulation of toll-like receptor (TLR)-4 in SCI gliosis lesion site, and this led us to focus on TLR-4 signaling in reactive astrocytes. Examination of primary astrocytes from TLR-4 knockout mice, and in vivo inhibition of TLR-4, revealed that the effect of IFN-b on the suppression of glial scar formation in SCI requires TLR-4 stimulation. These results suggest that IFN-b delivery via intravenous injection of NSCs following SCI inhibits glial scar formation in spinal cord through stimulation of TLR-4 signaling. |
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| 書誌情報 |
Cell Transplantation 発行日 2012-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0963-6897 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3727/096368912x657882 | |||||
