{"created":"2023-05-15T14:36:14.600626+00:00","id":46655,"links":{},"metadata":{"_buckets":{"deposit":"74a62299-4918-4c6d-aac0-fb54f7766b2c"},"_deposit":{"created_by":1,"id":"46655","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46655"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046655","sets":["1"]},"author_link":["465109","465107","465112","465108","465111","465110"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-09","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Cell Transplantation"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract\nGlial scar formation is the major impedence to axonal regrowth after spinal cord injury (SCI),\nand scar-modulating treatments have become a leading therapeutic goal for SCI treatment.\nIn this study human neural stem cells (NSCs) encoding interferon (IFN)-b gene were\nadministered intravenously to mice 1 week after spinal cord injury. Animals receiving NSCs encoding IFN-b exhibited significant neurobehavioral improvement, electrophysiological recovery, suppressed glial scar formation and preservation of nerve fibers in lesioned spinal cord.\nSystemic evaluation of SCI gliosis lesion site with lesion-specific microdissection, genomewide microarray  and MetaCore pathway analysis identified upregulation of toll-like receptor (TLR)-4 in SCI gliosis lesion site, and this led us to focus on TLR-4 signaling in reactive astrocytes. Examination of primary astrocytes from TLR-4 knockout mice, and in vivo inhibition of TLR-4, revealed that the effect of IFN-b on the suppression of glial scar formation in SCI requires TLR-4 stimulation. These results suggest that IFN-b delivery via intravenous injection of NSCs following SCI inhibits glial scar formation in spinal cord through stimulation of TLR-4 signaling.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3727/096368912x657882","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0963-6897","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishimura, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"465107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"465108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"465109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"465110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465112","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interferon-b delivery via human neural stem cell abates glial scar formation in spinal cord injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interferon-b delivery via human neural stem cell abates glial scar formation in spinal cord injury"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-02"},"publish_date":"2013-12-02","publish_status":"0","recid":"46655","relation_version_is_last":true,"title":["Interferon-b delivery via human neural stem cell abates glial scar formation in spinal cord injury"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:11.521211+00:00"}