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A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI
https://repo.qst.go.jp/records/46625
https://repo.qst.go.jp/records/4662541120d6a-4fc9-4c1c-89b5-c988c0b5dd45
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-25 | |||||
| タイトル | ||||||
| タイトル | A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kershaw, Jeffrey
× Kershaw, Jeffrey× Tomiyasu, Moyoko× Kashikura, Kenichi× Hirano, Yoshiyuki× Nonaka, Hiroi× Ikehira, Hiroo× Kanno, Iwao× Obata, Takayuki× et.al× Ｋｅｒｓｈａｗ Ｊｅｆｆｒｅｙ× 富安 もよこ× 柏倉 健一× 平野 好幸× 野中 博意× 池平 博夫× 菅野 巖× 小畠 隆行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new interpretation is proposed for stimulus-induced signal changes in diffusion-weighted functional MRI. T(2)-weighted spin-echo echo-planar images were acquired at different diffusion-weightings while visual stimulation was presented to human volunteers. The amplitudes of the positive stimulus-correlated response and post-stimulus undershoot (PSU) in the functional time-courses were found to follow different trends as a function of b-value. Data were analysed using a three-compartment signal model, with one compartment being purely vascular and the other two dominated by fast- and slow-diffusing molecules in the brain tissue. The diffusion coefficients of the tissue were assumed to be constant throughout the experiments. It is shown that the stimulus-induced signal changes can be decomposed into independent contributions originating from each of the three compartments. After decomposition, the fast-diffusion phase displays a substantial PSU, while the slow-diffusion phase demonstrates a highly reproducible and stimulus-correlated time-course with minimal undershoot. The decomposed responses are interpreted in terms of the spin-echo blood oxygenation level dependent (SE-BOLD) effect, and it is proposed that the signal produced by fast- and slow-diffusing molecules reflect a sensitivity to susceptibility changes in arteriole/venule- and capillary-sized vessels, respectively. This interpretation suggests that diffusion-weighted SE-BOLD imaging may provide subtle information about the haemodynamic and neuronal responses. Copyright (c) 2009 John Wiley & Sons, Ltd. | |||||
| 書誌情報 |
NMR in Biomedicine 巻 22, 号 7, p. 770-778, 発行日 2009-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0952-3480 | |||||
