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Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate
https://repo.qst.go.jp/records/46566
https://repo.qst.go.jp/records/465665acdcbc9-d769-4a9b-865f-69195492127c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-24 | |||||
| タイトル | ||||||
| タイトル | Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Maki
× Okada, Maki× Nakao, Ryuji× Momosaki, Sotaro× Yanamoto, Kazuhiko× Kikuchi, Tatsuya× Okamura, Toshimitsu× Wakizaka, Hidekatsu× Hosoi, Rie× Zhang, Ming-Rong× Inoue, Osamu× 岡田 真希× 柳本 和彦× 菊池 達矢× 岡村 敏充× 脇坂 秀克× 細井 理恵× 張 明栄× 井上 修 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract: Brain uptake of acetate is insufficient for obtaining a quantitative image of astrocytic oxidative metabolism. To improve brain uptake of [1-11C]acetate, we synthesized benzyl [1-11C]acetate ([1-11C]BA) and conducted a positron emission tomography (PET) study assessing astrocytic oxidative metabolism. Brain uptake of [1-11C]BA was markedly higher compared with [1-11C]acetate, and disappeared with a half-life of 20 minutes in all regions studied. Brain uptake of [1-11C]BA was significantly decreased by fluorocitrate. The results indicate that [1-11C]BA could be a useful PET probe for assessing astrocytic oxidative metabolism. | |||||
| 書誌情報 |
Applied Radiation and Isotopes 巻 78, p. 102-107, 発行日 2013-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.apradiso.2013.04.025 | |||||
