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Non-input analysis for incomplete trapping irreversible tracer with PET
https://repo.qst.go.jp/records/46565
https://repo.qst.go.jp/records/4656506aec3c1-e944-4d0f-97cf-1f209b6b0796
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-24 | |||||
| タイトル | ||||||
| タイトル | Non-input analysis for incomplete trapping irreversible tracer with PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohya, Tomoyuki
× Ohya, Tomoyuki× Kikuchi, Tatsuya× Fukumura, Toshimitsu× Zhang, Ming-Rong× Irie, Toshiaki× 大矢 智幸× 菊池 達矢× 福村 利光× 張 明栄× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: When using metabolic trapping type tracers, the tracers are not always trapped in the target tissue; i.e., some are completely trapped in the target, but others can be eliminated from the target tissue at a measurable rate. The tracers that can be eliminated are termed incomplete trapping irreversible tracers. These incomplete trapping irreversible tracers may be clinically useful when the tracer beta-value, the ratio of the tracer (metabolite) elimination rate to the tracer efflux rate, is under approximately 0.1. In this study, we propose a non-input analysis for incomplete trapping irreversible tracers based on the shape analysis (Shape), a non-input analysis used for irreversible tracers. Methods: A Monte Carlo simulation study based on experimental monkey data with two actual PET tracers (a complete trapping irreversible tracer [11C]MP4A and an incomplete trapping irreversible tracer [18 F]FEP- 4MA) was performed to examine the effects of the environmental error and the tracer elimination rate on the estimation of the k3-parameter (corresponds to metabolic rate) using Shape (original) and modified Shape (M-Shape) analysis. The simulation results were also compared with the experimental results obtained with the two PET tracers. Results: When the tracer beta-value was over 0.03, the M-Shape method was superior to the Shape method for the estimation of the k3-parameter. The simulation results were also in reasonable agreement with the experimental ones. Conclusions: M-Shape can be used as the non-input analysis of incomplete trapping irreversible tracers for PET study. |
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| 書誌情報 |
Nuclear Medicine and Biology 巻 40, 号 5, p. 664-669, 発行日 2012-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | org/10.1016/j.nucmedbio.2013.02.012 | |||||
