{"created":"2023-05-15T14:36:10.365755+00:00","id":46565,"links":{},"metadata":{"_buckets":{"deposit":"12892336-5a98-41bb-9ae8-14eb30fa16df"},"_deposit":{"created_by":1,"id":"46565","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46565"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046565","sets":["1"]},"author_link":["464102","464103","464097","464098","464105","464099","464101","464104","464096","464100"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"669","bibliographicPageStart":"664","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: When using metabolic trapping type tracers, the tracers are not always trapped in the target\ntissue; i.e., some are completely trapped in the target, but others can be eliminated from the target tissue at a\nmeasurable rate. The tracers that can be eliminated are termed incomplete trapping irreversible tracers.\nThese incomplete trapping irreversible tracers may be clinically useful when the tracer beta-value, the ratio of\nthe tracer (metabolite) elimination rate to the tracer efflux rate, is under approximately 0.1. In this study, we\npropose a non-input analysis for incomplete trapping irreversible tracers based on the shape analysis (Shape),\na non-input analysis used for irreversible tracers.\nMethods: A Monte Carlo simulation study based on experimental monkey data with two actual PET tracers (a\ncomplete trapping irreversible tracer [11C]MP4A and an incomplete trapping irreversible tracer [18 F]FEP-\n4MA) was performed to examine the effects of the environmental error and the tracer elimination rate on the\nestimation of the k3-parameter (corresponds to metabolic rate) using Shape (original) and modified Shape\n(M-Shape) analysis. The simulation results were also compared with the experimental results obtained with\nthe two PET tracers.\nResults: When the tracer beta-value was over 0.03, the M-Shape method was superior to the Shape method for\nthe estimation of the k3-parameter. The simulation results were also in reasonable agreement with the\nexperimental ones.\nConclusions: M-Shape can be used as the non-input analysis of incomplete trapping irreversible tracers for\nPET study.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"org/10.1016/j.nucmedbio.2013.02.012","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohya, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"464096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"464097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"464098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"464099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"464100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢 智幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464105","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Non-input analysis for incomplete trapping irreversible tracer with PET","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Non-input analysis for incomplete trapping irreversible tracer with PET"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-24"},"publish_date":"2013-06-24","publish_status":"0","recid":"46565","relation_version_is_last":true,"title":["Non-input analysis for incomplete trapping irreversible tracer with PET"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:50:14.732222+00:00"}