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Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice
https://repo.qst.go.jp/records/46562
https://repo.qst.go.jp/records/4656292a8281f-fd02-405a-8f8d-6b6fd75fffd0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-18 | |||||
| タイトル | ||||||
| タイトル | Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuji, Hideo
× Tsuji, Hideo× Ishii-Ohba, Hiroko× Shiomi, Tadahiro× Shiomi, Naoko× Katsube, Takanori× Mori, Masahiko× Nenoi, Mitsuru× Nakabeppu, Yusaku× Tatsumi, Kouichi× Muto, Masahiro× Sado, Toshihiko× et.al× 辻 秀雄× 石井 洋子× 塩見 忠博× 塩見 尚子× 勝部 孝則× 森 雅彦× 根井 充× 巽 紘一× 武藤 正弘× 佐渡 敏彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Changes in the thymic microenvironment lead to radiation-induced thymic lymphomagenesis, but the phenomena are not fully understood. Here we show that radiation-induced chromosomal instability and bystander effects occur in thymocytes and are involved in lymphomagenesis in C57BL/6 mice that have been irradiated four times with 1.8-Gy gamma-rays. Reactive oxygen species (ROS) were generated in descendants of irradiated thymocytes during recovery from radiation-induced thymic atrophy. Concomitantly, descendants of irradiated thymocytes manifested DNA lesions as revealed by gamma-H2AX foci, chromosomal instability, aneuploidy with trisomy 15 and bystander effects on chromosomal aberration induction in co-cultured ROS-sensitive mutant cells, suggesting that the delayed generation of ROS is a primary cause of these phenomena. Abolishing the bystander effect of post-irradiation thymocytes by superoxide dismutase and catalase supports ROS involvement. Chromosomal instability in thymocytes resulted in the generation of abnormal cell clones bearing trisomy 15 and aberrant karyotypes in the thymus. The emergence of thymic lymphomas from the thymocyte population containing abnormal cell clones indicated that clones with trisomy 15 and altered karyotypes were prelymphoma cells with the potential to develop into thymic lymphomas. The oncogene Notch1 was rearranged after the prelymphoma cells were established. Thus, delayed nontargeted radiation effects drive thymic lymphomagenesis through the induction of characteristic changes in intrathymic immature T cells and the generation of prelymphoma cells. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 54, p. 453-466, 発行日 2013-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrs128 | |||||
