@article{oai:repo.qst.go.jp:00046562,
 author = {Tsuji, Hideo and Ishii-Ohba, Hiroko and Shiomi, Tadahiro and Shiomi, Naoko and Katsube, Takanori and Mori, Masahiko and Nenoi, Mitsuru and Nakabeppu, Yusaku and Tatsumi, Kouichi and Muto, Masahiro and Sado, Toshihiko and et.al and 辻 秀雄 and 石井 洋子 and 塩見 忠博 and 塩見 尚子 and 勝部 孝則 and 森 雅彦 and 根井 充 and 巽 紘一 and 武藤 正弘 and 佐渡 敏彦},
 journal = {Journal of Radiation Research},
 month = {Jan},
 note = {Changes in the thymic microenvironment lead to radiation-induced thymic lymphomagenesis, but the phenomena are not fully understood. Here we show that radiation-induced chromosomal instability and bystander effects occur in thymocytes and are involved in lymphomagenesis in C57BL/6 mice that have been irradiated four times with 1.8-Gy gamma-rays. Reactive oxygen species (ROS) were generated in descendants of irradiated thymocytes during recovery from radiation-induced thymic atrophy. Concomitantly, descendants of irradiated thymocytes manifested DNA lesions as revealed by gamma-H2AX foci, chromosomal instability, aneuploidy with trisomy 15 and bystander effects on chromosomal aberration induction in co-cultured ROS-sensitive mutant cells, suggesting that the delayed generation of ROS is a primary cause of these phenomena. Abolishing the bystander effect of post-irradiation thymocytes by superoxide dismutase and catalase supports ROS involvement. Chromosomal instability in thymocytes resulted in the generation of abnormal cell clones bearing trisomy 15 and aberrant karyotypes in the thymus. The emergence of thymic lymphomas from the thymocyte population containing abnormal cell clones indicated that clones with trisomy 15 and altered karyotypes were prelymphoma cells with the potential to develop into thymic lymphomas. The oncogene Notch1 was rearranged after the prelymphoma cells were established. Thus, delayed nontargeted radiation effects drive thymic lymphomagenesis through the induction of characteristic changes in intrathymic immature T cells and the generation of prelymphoma cells.},
 pages = {453--466},
 title = {Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice},
 volume = {54},
 year = {2013}
}