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Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride
https://repo.qst.go.jp/records/46544
https://repo.qst.go.jp/records/46544e9bf8573-9390-4b3f-9bbb-f6d3cbfd6969
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-02 | |||||
| タイトル | ||||||
| タイトル | Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kodaka, Fumitoshi
× Kodaka, Fumitoshi× Ito, Hiroshi× Kimura, Yasuyuki× Fujie, Saori× Takano, Harumasa× Fujiwara, Hironobu× Sasaki, Takeshi× Nakayama, Kazuhiko× Halldin, Christer× Farde, Lars× Suhara, Tetsuya× 小高 文聰× 伊藤 浩× 木村 泰之× 藤江 沙織× 高野 晴成× 藤原 広臨× 佐々木 健至× ハルディン クリスタ× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Dopamine D2/3 receptors (D2/3Rs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D2/3HIGH), which has a high affinity for endogenous dopamine, and low-affinity state (D2/3LOW). The density of D2/3HIGH can be measured with (R)-2-11CH3O-N-n-propylnorapomorphine ([11C]MNPA), while total density of D2/3HIGH and D2/3LOW (D2/3Rs) can be measured with [11C]raclopride using positron emission tomography (PET). Thus, the ratio of the binding potential (BP) of [11C]MNPA to that of [11C]raclopride ([11C]MNPA/[11C]raclopride) may reflect the proportion of the density of D2/3HIGH to that of D2/3Rs. In the caudate and putamen, [11C]MNPA/[11C]raclopride reflects the proportion of the density of D2HIGH to that of D2Rs. To evaluate the reliability of the PET paradigm with [11C]MNPA and [11C]raclopride, we investigated the test-retest reproducibility of non-displaceable BP (BPND) measured with [11C]MNPA, and of [11C]MNPA/[11C]raclopride in healthy humans. Methods: Eleven healthy male volunteers underwent two sets of PET studies on separate days that each included [11C]MNPA and [11C]raclopride scans. BPND values in the caudate and putamen were calculated. Test-retest reproducibility of BPND of [11C]MNPA, and [11C]MNPA/[11C]raclopride, was assessed by intra-subject variability (absolute variability) and test-retest reliability (intra-class correlation coefficient: ICC). Results: The absolute variability of [11C]MNPA BPND was 5.30 +- 3.96% and 12.3 +- 7.95% and the ICC values of [11C]MNPA BPND were 0.72 and 0.82 in the caudate and putamen, respectively. The absolute variability of [11C]MNPA/[11C]raclopride was 6.11 +- 3.68% and 11.60 +- 5.70% and the ICC values of [11C]MNPA/[11C]raclopride were 0.79 and 0.80 in the caudate and putamen, respectively. Conclusion: In the present preliminary study, the test-retest reproducibility of BPND of [11C]MNPA and of [11C]MNPA/[11C]raclopride was reliable in the caudate and putamen. |
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| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 40, 号 4, p. 574-579, 発行日 2013-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
