{"created":"2023-05-15T14:36:09.455223+00:00","id":46544,"links":{},"metadata":{"_buckets":{"deposit":"c0a9b7b1-7737-45cb-aaca-3bff6b0af717"},"_deposit":{"created_by":1,"id":"46544","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46544"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046544","sets":["1"]},"author_link":["463848","463862","463866","463859","463853","463860","463858","463847","463849","463863","463864","463852","463856","463857","463851","463855","463861","463865","463854","463850"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"579","bibliographicPageStart":"574","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"European Journal of Nuclear Medicine and Molecular Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Dopamine D2/3 receptors (D2/3Rs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D2/3HIGH), which has a high affinity for endogenous dopamine, and low-affinity state (D2/3LOW). The density of D2/3HIGH can be measured with (R)-2-11CH3O-N-n-propylnorapomorphine ([11C]MNPA), while total density of D2/3HIGH and D2/3LOW (D2/3Rs) can be measured with [11C]raclopride using positron emission tomography (PET). Thus, the ratio of the binding potential (BP) of [11C]MNPA to that of [11C]raclopride ([11C]MNPA/[11C]raclopride) may reflect the proportion of the density of D2/3HIGH to that of D2/3Rs. In the caudate and putamen, [11C]MNPA/[11C]raclopride reflects the proportion of the density of D2HIGH to that of D2Rs. To evaluate the reliability of the PET paradigm with [11C]MNPA and [11C]raclopride, we investigated the test-retest reproducibility of non-displaceable BP (BPND) measured with [11C]MNPA, and of [11C]MNPA/[11C]raclopride in healthy humans.\nMethods: Eleven healthy male volunteers underwent two sets of PET studies on separate days that each included [11C]MNPA and [11C]raclopride scans. BPND values in the caudate and putamen were calculated. Test-retest reproducibility of BPND of [11C]MNPA, and  [11C]MNPA/[11C]raclopride, was assessed by intra-subject variability (absolute variability) and test-retest reliability (intra-class correlation coefficient: ICC). \nResults: The absolute variability of [11C]MNPA BPND was 5.30 +- 3.96% and 12.3 +- 7.95% and the ICC values of [11C]MNPA BPND were 0.72 and 0.82 in the caudate and putamen, respectively. The absolute variability of [11C]MNPA/[11C]raclopride was 6.11 +- 3.68% and 11.60 +- 5.70% and the ICC values of [11C]MNPA/[11C]raclopride were 0.79 and 0.80 in the caudate and putamen, respectively.\nConclusion: In the present preliminary study, the test-retest reproducibility of BPND of [11C]MNPA and of [11C]MNPA/[11C]raclopride was reliable in the caudate and putamen.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1619-7070","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kodaka, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"463847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"463848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"463849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujie, Saori"}],"nameIdentifiers":[{"nameIdentifier":"463850","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"463851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujiwara, Hironobu"}],"nameIdentifiers":[{"nameIdentifier":"463852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"463853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakayama, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"463854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Halldin, Christer"}],"nameIdentifiers":[{"nameIdentifier":"463855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Farde, Lars"}],"nameIdentifiers":[{"nameIdentifier":"463856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"463857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤江 沙織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 健至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハルディン クリスタ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463866","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-02"},"publish_date":"2013-05-02","publish_status":"0","recid":"46544","relation_version_is_last":true,"title":["Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:50:30.064292+00:00"}