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Microarray CGH analyses of chromosomal 20q deletions in patients with hematopoietic malignancies
https://repo.qst.go.jp/records/46462
https://repo.qst.go.jp/records/46462f0164540-2cd9-4bd8-8de5-0acc44e57b0a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-06 | |||||
| タイトル | ||||||
| タイトル | Microarray CGH analyses of chromosomal 20q deletions in patients with hematopoietic malignancies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Michiko
× Okada, Michiko× Suto, Yumiko× Hirai, Momoki× Motoji, Toshiko× et.al× 數藤 由美子× 平井 百樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Del(20q) is a chromosomal abnormality mostly found in various myeloid disorders, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML). Here, microarray comparative genomic hybridization (aCGH) analyses in twelve out of 14 patients cytogenetically confirmed to carry the del(20q) aberration in their bone marrow, demonstrated that all deletions were interstitial, and both the proximal and distal breakpoints varied among individuals. The centromeric breakpoints were located in the 20q11.21-12 region, and the telomeric breakpoints, in the 20q13.13-13.33 region. The extent of the deletion ranged from 11.2 to 27.3 Mb, and the commonly deleted region (CDR) was estimated to be 7.2 Mb in size. Two commonly retained regions (CRR) were present, the proximal one adjacent to the centromere (20q11.1-11.21) and the subtelomeric one (20q13.33). The CDR of our study was more distal than reported previously. As the size and breakpoints of del(20q) have been reported to vary among patients, the presence of one or more tumor suppressor genes in the CDR has been suggested. Our study will contribute to the identification of candidate tumor suppressor genes on 20q. Fluorescence in situ hybridization (FISH) demonstrated that del(20q) cells were detected at a higher frequency in karyotype analyses than in interphase FISH and aCGH analyses in 3 patients. | |||||
| 書誌情報 |
Cancer Genetics 巻 205, 号 1/2, p. 18-24, 発行日 2012-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2210-7762 | |||||
