@article{oai:repo.qst.go.jp:00046462,
 author = {Okada, Michiko and Suto, Yumiko and Hirai, Momoki and Motoji, Toshiko and et.al and 數藤 由美子 and 平井 百樹},
 issue = {1/2},
 journal = {Cancer Genetics},
 month = {Jan},
 note = {Del(20q) is a chromosomal abnormality mostly found in various myeloid disorders, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML).  Here, microarray comparative genomic hybridization (aCGH) analyses in twelve out of 14 patients cytogenetically confirmed to carry the del(20q) aberration in their bone marrow, demonstrated that all deletions were interstitial, and both the proximal and distal breakpoints varied among individuals.  The centromeric breakpoints were located in the 20q11.21-12 region, and the telomeric breakpoints, in the 20q13.13-13.33 region.  The extent of the deletion ranged from 11.2 to 27.3 Mb, and the commonly deleted region (CDR) was estimated to be 7.2 Mb in size.  Two commonly retained regions (CRR) were present, the proximal one adjacent to the centromere (20q11.1-11.21) and the subtelomeric one (20q13.33).  The CDR of our study was more distal than reported previously.  As the size and breakpoints of del(20q) have been reported to vary among patients, the presence of one or more tumor suppressor genes in the CDR has been suggested.  Our study will contribute to the identification of candidate tumor suppressor genes on 20q.  Fluorescence in situ hybridization (FISH) demonstrated that del(20q) cells were detected at a higher frequency in karyotype analyses than in interphase FISH and aCGH analyses in 3 patients.},
 pages = {18--24},
 title = {Microarray CGH analyses of chromosomal 20q deletions in patients with hematopoietic malignancies},
 volume = {205},
 year = {2012}
}