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What Can Be Seen by 18F-FDG PET in Atherosclerosis Imaging? The Effect of Foam Cell Formation on 18F-FDG Uptake to Macrophages In Vitro
https://repo.qst.go.jp/records/46356
https://repo.qst.go.jp/records/463563892d7be-671f-4360-b2cf-6ba173c15c59
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-07-09 | |||||
| タイトル | ||||||
| タイトル | What Can Be Seen by 18F-FDG PET in Atherosclerosis Imaging? The Effect of Foam Cell Formation on 18F-FDG Uptake to Macrophages In Vitro | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mikako, Ogawa
× Mikako, Ogawa× Nakamura, Satoki× Saito, Yuriko× Kosugi, Mutsumi× Magata, Yasuhiro× 齋藤 有里子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 18F-FDG PET is a promising tool for detecting vulnerable plaques, depending on the extent of macrophage infiltration; however, it is still not clear which stage of the lesion can be detected by 18F-FDG PET. Methods: In this study, we investigated the effect of foam cell formation on 18F-FDG uptake using cultured mouse peritoneal macrophages. Results: 18F-FDG accumulation was increased by foam cell formation, but the uptake was decreased to the control level after complete differentiation to foam cells. Changes in hexokinase activity tended to accompany changes in 18F-FDG uptake. In contrast, changes in glucose-6-phosphatase activity and glucose transporter 1 expression did not parallel 18F-FDG uptake. Conclusion: Our results suggest that 18F-FDG PET detects the early stage of foam cell formation in atherosclerosis. |
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| 書誌情報 |
Journal of Nuclear Medicine 巻 53, 号 1, p. 55-58, 発行日 2011-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0161-5505 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2967/jnumed.111.092866 | |||||
