@article{oai:repo.qst.go.jp:00046356,
 author = {Mikako, Ogawa and Nakamura, Satoki and Saito, Yuriko and Kosugi, Mutsumi and Magata, Yasuhiro and 齋藤 有里子},
 issue = {1},
 journal = {Journal of Nuclear Medicine},
 month = {Nov},
 note = {18F-FDG PET is a promising tool for detecting vulnerable
plaques, depending on the extent of macrophage infiltration;
however, it is still not clear which stage of the lesion can be
detected by 18F-FDG PET. Methods: In this study, we investigated
the effect of foam cell formation on 18F-FDG uptake using
cultured mouse peritoneal macrophages. Results: 18F-FDG
accumulation was increased by foam cell formation, but the
uptake was decreased to the control level after complete differentiation
to foam cells. Changes in hexokinase activity
tended to accompany changes in 18F-FDG uptake. In contrast,
changes in glucose-6-phosphatase activity and glucose transporter
1 expression did not parallel 18F-FDG uptake. Conclusion:
Our results suggest that 18F-FDG PET detects the early
stage of foam cell formation in atherosclerosis.},
 pages = {55--58},
 title = {What Can Be Seen by 18F-FDG PET in Atherosclerosis Imaging? The Effect of Foam Cell Formation on 18F-FDG Uptake to Macrophages In Vitro},
 volume = {53},
 year = {2011}
}