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High-yield automated synthesis of[18F]fluoroazomycin arabinoside([18F]FAZA) for hypoxia-specific tumor imaging
https://repo.qst.go.jp/records/46327
https://repo.qst.go.jp/records/463278c2bff0f-1522-4cc2-a9c6-9cb64fcb90f3
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-05-29 | |||||
| タイトル | ||||||
| タイトル | High-yield automated synthesis of[18F]fluoroazomycin arabinoside([18F]FAZA) for hypoxia-specific tumor imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hayashi, Kazutaka
× Hayashi, Kazutaka× Furutsuka, Kenji× Takei, Makoto× Mutou, Masatoshi× Nakao, Ryuji× Aki, Hatsumi× Suzuki, Kazutoshi× Fukumura, Toshimitsu× 古塚 賢士× 鈴木 和年× 福村 利光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aimofthisstudywastodevelopanefficientfullyautomatedsynthesismethodtoachieveahigh radiochemicalyieldof[18F]FAZA withasmallamountofprecursor.Asmallcartridgecontaining25mgof theQMAresinwaspreparedandevaluatedtoobtain[18F]F1 in asmallquantityofbase(K2CO3), which might allowtheuseofasmallamountofprecursor. Thelabelingandhydrolyzingconditionsfor[18F]FAZA synthesiswerealsoinvestigatedmanually.No-carrier-added[18F]F1 was trappedonthesmallQMA cartridgeandelutedwithamixtureofKrytofix222(2.26mg,6.0 mmol)andK2CO3 (0.69 mg,5.0 mmol)in 70%MeCN(0.4mL).Theautomatedsynthesisof[18F]FAZA wasoptimallyperformedwithamodifiedNIRS originalsynthesissystemforclinicaluse,bylabeling2.5mg(5.2 mmol)oftheprecursorinDMSO(0.4mL)at 120 1C for10min,andthenbyhydrolyzingthe 18F-labeledintermediatewith0.1MNaOH(0.5mL)atroom temperaturefor3min.Usingtheabovecondition,the[18F]FAZAinjectionwasobtainedwithahigh radiochemicalyieldof52.475.3%(decay-corrected, n¼8) within50.571.5min. |
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| 書誌情報 |
Applied Radiation and Isotopes 巻 69, 号 7, p. 1007-1013, 発行日 2011-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.apradiso.2011.02.025 | |||||
