@article{oai:repo.qst.go.jp:00046327,
 author = {Hayashi, Kazutaka and Furutsuka, Kenji and Takei, Makoto and Mutou, Masatoshi and Nakao, Ryuji and Aki, Hatsumi and Suzuki, Kazutoshi and Fukumura, Toshimitsu and 古塚 賢士 and 鈴木 和年 and 福村 利光},
 issue = {7},
 journal = {Applied Radiation and Isotopes},
 month = {Feb},
 note = {The aimofthisstudywastodevelopanefficientfullyautomatedsynthesismethodtoachieveahigh
radiochemicalyieldof[18F]FAZA withasmallamountofprecursor.Asmallcartridgecontaining25mgof
theQMAresinwaspreparedandevaluatedtoobtain[18F]F1 in asmallquantityofbase(K2CO3), which
might allowtheuseofasmallamountofprecursor. Thelabelingandhydrolyzingconditionsfor[18F]FAZA
synthesiswerealsoinvestigatedmanually.No-carrier-added[18F]F1 was trappedonthesmallQMA
cartridgeandelutedwithamixtureofKrytofix222(2.26mg,6.0 mmol)andK2CO3 (0.69 mg,5.0 mmol)in
70%MeCN(0.4mL).Theautomatedsynthesisof[18F]FAZA wasoptimallyperformedwithamodifiedNIRS
originalsynthesissystemforclinicaluse,bylabeling2.5mg(5.2 mmol)oftheprecursorinDMSO(0.4mL)at
120 1C for10min,andthenbyhydrolyzingthe 18F-labeledintermediatewith0.1MNaOH(0.5mL)atroom
temperaturefor3min.Usingtheabovecondition,the[18F]FAZAinjectionwasobtainedwithahigh
radiochemicalyieldof52.475.3%(decay-corrected, n¼8) within50.571.5min.},
 pages = {1007--1013},
 title = {High-yield automated synthesis of[18F]fluoroazomycin arabinoside([18F]FAZA) for hypoxia-specific tumor imaging},
 volume = {69},
 year = {2011}
}