WEKO3
-
RootNode
アイテム
Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2).
https://repo.qst.go.jp/records/46262
https://repo.qst.go.jp/records/4626299238a41-e075-405b-88c4-2c058dc9bab4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-02-06 | |||||
| タイトル | ||||||
| タイトル | Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2). | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toita, Takafumi
× Toita, Takafumi× Kato, Shingo× Niibe, Yuzuru× Ohno, Tatsuya× Kazumoto, Tomoko× Kodaira, Takeshi× Shikama, Naoto× Kenjo, Masahiro× Tokumaru, Sunao× Yamauchi, Chikako× Suzuki, Osamu× Sakurai, Hideyuki× Numasaki, Hodaka× Teshima, Teruki× Oguchi, Masahiko× Kagami, Yoshikazu× Nakano, Takashi× Hiraoka, Masahiro× Mitsuhashi, Norio× 加藤 眞吾× 古平 毅× 手島 昭樹× 小口 正彦 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. METHODS AND MATERIALS: \nEligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size <40 mm in diameter (assessed by T2-weighted magnetic resonance imaging), and no pelvic/para-aortic lymphadenopathy. The treatment protocol consisted of whole-pelvis external beam radiotherapy (EBRT) of 20 Gy/10 fractions, pelvic EBRT with midline block of 30 Gy/15 fractions, and HDR-ICBT of 24 Gy/4 fractions (at point A). The cumulative biologically effective dose (BED) was 62 Gy(10) (a/b = 10) at point A. The primary endpoint was the 2-year pelvic disease progression-free (PDPF) rate. All patients received a radiotherapy quality assurance review. RESULTS: \nBetween September 2004 and July 2007, 60 eligible patients were enrolled. Thirty-six patients were assessed with FIGO stage Ib1; 12 patients with stage IIa; and 12 patients with stage IIb. Median tumor diameter was 28 mm (range, 6-39 mm). Median overall treatment time was 43 days. Median follow-up was 49 months (range, 7-72 months). Seven patients developed recurrences: 3 patients had pelvic recurrences (2 central, 1 nodal), and 4 patients had distant metastases. The 2-year PDPF was 96% (95% confidence interval [CI], 92%-100%). The 2-year disease-free and overall survival rates were 90% (95% CI, 82%-98%) and 95% (95% CI, 89%-100%), respectively. The 2-year late complication rates (according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer of Grade ≥1) were 18% (95% CI, 8%-28%) for large intestine/rectum, 4% (95% CI, 0%-8%) for small intestine, and 0% for bladder. No Grade ≥3 cases were observed for genitourinary/gastrointestinal late complications. CONCLUSIONS: \nThese results suggest that definitive radiotherapy using HDR-ICBT with a low cumulative dose schedule (BED, 62 Gy(10) at point A) can provide excellent local control without severe toxicity in nonbulky (<4-cm) early-stage cervical cancer. |
|||||
| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 82, 号 1, p. e49-56, 発行日 2011-04 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2011.01.022 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.redjournal.org/article/S0360-3016%2811%2900153-2/abstract | |||||
| 関連名称 | http://www.redjournal.org/article/S0360-3016%2811%2900153-2/abstract | |||||
Share
Cite as
Toita, Takafumi, Kato, Shingo, Niibe, Yuzuru, Ohno, Tatsuya, Kazumoto, Tomoko, Kodaira, Takeshi, Shikama, Naoto, Kenjo, Masahiro, Tokumaru, Sunao, Yamauchi, Chikako, Suzuki, Osamu, Sakurai, Hideyuki, Numasaki, Hodaka, Teshima, Teruki, Oguchi, Masahiko, Kagami, Yoshikazu, Nakano, Takashi, Hiraoka, Masahiro, Mitsuhashi, Norio, 加藤 眞吾, 古平 毅, 手島 昭樹, 小口 正彦, n.d., Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2).: e49–56 p.
Loading...
