{"created":"2023-05-15T14:35:57.009330+00:00","id":46262,"links":{},"metadata":{"_buckets":{"deposit":"3d107178-f739-4f35-bae7-3eedfd4a5635"},"_deposit":{"created_by":1,"id":"46262","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46262"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046262","sets":["1"]},"author_link":["460739","460737","460746","460731","460727","460741","460747","460726","460728","460734","460744","460735","460730","460733","460729","460745","460738","460736","460740","460748","460732","460742","460743"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"56","bibliographicPageStart":"e49","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study.\nMETHODS AND MATERIALS:\n\\nEligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size <40 mm in diameter (assessed by T2-weighted magnetic resonance imaging), and no pelvic/para-aortic lymphadenopathy. The treatment protocol consisted of whole-pelvis external beam radiotherapy (EBRT) of 20 Gy/10 fractions, pelvic EBRT with midline block of 30 Gy/15 fractions, and HDR-ICBT of 24 Gy/4 fractions (at point A). The cumulative biologically effective dose (BED) was 62 Gy(10) (a/b = 10) at point A. The primary endpoint was the 2-year pelvic disease progression-free (PDPF) rate. All patients received a radiotherapy quality assurance review.\nRESULTS:\n\\nBetween September 2004 and July 2007, 60 eligible patients were enrolled. Thirty-six patients were assessed with FIGO stage Ib1; 12 patients with stage IIa; and 12 patients with stage IIb. Median tumor diameter was 28 mm (range, 6-39 mm). Median overall treatment time was 43 days. Median follow-up was 49 months (range, 7-72 months). Seven patients developed recurrences: 3 patients had pelvic recurrences (2 central, 1 nodal), and 4 patients had distant metastases. The 2-year PDPF was 96% (95% confidence interval [CI], 92%-100%). The 2-year disease-free and overall survival rates were 90% (95% CI, 82%-98%) and 95% (95% CI, 89%-100%), respectively. The 2-year late complication rates (according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer of Grade &#8805;1) were 18% (95% CI, 8%-28%) for large intestine/rectum, 4% (95% CI, 0%-8%) for small intestine, and 0% for bladder. No Grade &#8805;3 cases were observed for genitourinary/gastrointestinal late complications.\nCONCLUSIONS:\n\\nThese results suggest that definitive radiotherapy using HDR-ICBT with a low cumulative dose schedule (BED, 62 Gy(10) at point A) can provide excellent local control without severe toxicity in nonbulky (<4-cm) early-stage cervical cancer.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijrobp.2011.01.022","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.redjournal.org/article/S0360-3016%2811%2900153-2/abstract"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.redjournal.org/article/S0360-3016%2811%2900153-2/abstract","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Toita, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"460726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"460727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niibe, Yuzuru"}],"nameIdentifiers":[{"nameIdentifier":"460728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"460729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazumoto, Tomoko"}],"nameIdentifiers":[{"nameIdentifier":"460730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodaira, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"460731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shikama, Naoto"}],"nameIdentifiers":[{"nameIdentifier":"460732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenjo, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"460733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokumaru, Sunao"}],"nameIdentifiers":[{"nameIdentifier":"460734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Chikako"}],"nameIdentifiers":[{"nameIdentifier":"460735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"460736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"460737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Numasaki, Hodaka"}],"nameIdentifiers":[{"nameIdentifier":"460738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Teshima, Teruki"}],"nameIdentifiers":[{"nameIdentifier":"460739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oguchi, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"460740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kagami, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"460741","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"460742","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiraoka, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"460743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsuhashi, Norio"}],"nameIdentifiers":[{"nameIdentifier":"460744","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460745","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古平 毅","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460746","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"手島 昭樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小口 正彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460748","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2).","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-06"},"publish_date":"2012-02-06","publish_status":"0","recid":"46262","relation_version_is_last":true,"title":["Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:53:57.595783+00:00"}