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アイテム
Reprogramming of mouse and human cells to pluripotency using mature microRNAs.
https://repo.qst.go.jp/records/46223
https://repo.qst.go.jp/records/462236b494f2d-4314-419e-9e10-7abb438a1a7b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-12-16 | |||||
| タイトル | ||||||
| タイトル | Reprogramming of mouse and human cells to pluripotency using mature microRNAs. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Miyoshi, Norikatsu
× Miyoshi, Norikatsu× Ishii, Hideshi× Nagano, Hiroaki× Haraguchi, Naotsugu× Mimori, Koshi× Saito, Toshiyuki× Ikeda, Masataka× Yamamoto, Hirofumi× Sekimoto, Mitsugu× Doki, Yuichiro× Mori, Masaki× et.al× 石井 秀始× 齋藤 俊行× 関本 貢嗣 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Induced pluripotent stem cells (iPSCs) can be generated from differentiated human and mouse somatic cells using transcription factors such as Oct4, Sox2, Klf4, and c-Myc. It is possible to augment the reprogramming process with chemical compounds, but issues related to low reprogramming efficiencies and, with a number of protocols, residual vector sequences, remain to be resolved. We show here that it is possible to reprogram mouse and human cells to pluripotency by direct transfection of mature double-stranded microRNAs (miRNAs). Our approaches use a combination of mir-200c plus mir-302 s and mir-369 s family miRNAs. Because this reprogramming method does not require vector-based gene transfer, it holds significant potential for biomedical research and regenerative medicine. | |||||
| 書誌情報 |
Cell Stem Cell 巻 8, 号 6, p. 633-638, 発行日 2011-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1934-5909 | |||||
