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Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors
https://repo.qst.go.jp/records/46201
https://repo.qst.go.jp/records/462014b6361c5-88f8-49c0-87c9-9d124ff4b8c3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-11-09 | |||||
| タイトル | ||||||
| タイトル | Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Asakawa, Chiharu
× Asakawa, Chiharu× Ogawa, Masanao× Kumata, Katsushi× Fujinaga, Masayuki× Yamasaki, Tomoteru× Xie, Lin× Yui, Joji× Kawamura, Kazunori× Fukumura, Toshimitsu× Zhang, Ming-Rong× 浅川 千春× 小川 政直× 熊田 勝志× 藤永 雅之× 山崎 友照× 謝 琳× 由井 譲二× 河村 和紀× 福村 利光× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Three ureido-substituted benzenesulfonamides 1a–c have been developed as potent inhibitors for carbonic anhydrase IX, which is overexpressed in hypoxic tumors. In this study, we labeled these unsymmetrical ureas 1a–c using [11C]phosgene ([11C]COCl2) as a labeling agent with the expectation that [11C]1a–c could become promising positron tomography probes for imaging carbonic anhydrase IX in tumors. The strategy for radiosynthesis of [11C]1a–c was to react hydrochloride of anilines 2a–c with [11C]COCl2 to give isocyanate [11C]4a–c, followed by a reaction with 4-aminobenzenesulfonamide (3). | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 21, 号 23, p. 7017-7020, 発行日 2011-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
