@article{oai:repo.qst.go.jp:00046201,
 author = {Asakawa, Chiharu and Ogawa, Masanao and Kumata, Katsushi and Fujinaga, Masayuki and Yamasaki, Tomoteru and Xie, Lin and Yui, Joji and Kawamura, Kazunori and Fukumura, Toshimitsu and Zhang, Ming-Rong and 浅川 千春 and 小川 政直 and 熊田 勝志 and 藤永 雅之 and 山崎 友照 and 謝 琳 and 由井 譲二 and 河村 和紀 and 福村 利光 and 張 明栄},
 issue = {23},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {Dec},
 note = {Three ureido-substituted benzenesulfonamides 1a–c have been developed as potent inhibitors for carbonic anhydrase IX, which is overexpressed in hypoxic tumors. In this study, we labeled these unsymmetrical ureas 1a–c using [11C]phosgene ([11C]COCl2) as a labeling agent with the expectation that [11C]1a–c could become promising positron tomography probes for imaging carbonic anhydrase IX in tumors. The strategy for radiosynthesis of [11C]1a–c was to react hydrochloride of anilines 2a–c with [11C]COCl2 to give isocyanate [11C]4a–c, followed by a reaction with 4-aminobenzenesulfonamide (3).},
 pages = {7017--7020},
 title = {Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors},
 volume = {21},
 year = {2011}
}