WEKO3
アイテム
ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM
https://repo.qst.go.jp/records/46179
https://repo.qst.go.jp/records/4617993841fa8-b37f-402a-9d81-ba7b64a294b9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-07 | |||||
| タイトル | ||||||
| タイトル | ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sato, Tatsuhiko
× Sato, Tatsuhiko× Watanabe, Ritsuko× Kase, Yuki× Tsuruoka, Chizuru× Suzuki, Masao× Furusawa, Yoshiya× Niita, Koji× 鶴岡 千鶴× 鈴木 雅雄× 古澤 佳也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is considered that the linear energy transfer (LET) may not be the ideal index for expressing the relative biological effective- ness (RBE) of cell killing for heavy-ion irradiation, as the ion-species dependencies have clearly been observed in the relation between LET and RBE derived from cell-survival fraction data. The previously measured survival fractions of four cell lines irra- diated by various ion species, employing the saturation-corrected dose-mean lineal energy, y*, instead of LET as the index of the RBE were therefore re-analysed. In the analysis, the initial slopes of the survival fractions, the so-called a-parameter in the linear-quadratic model, were plotted as a function of y*, which was calculated by the microdosimetric kinetic (MK) model implemented in the Particle and Heavy Ion Transport code System. It was found from the analysis that the ion-species depen- dencies observed in the relations between a and LET disappeared from those between a and y*, and their relations can be well reproduced by a simple equation derived from the MK model. These results clearly indicate the suitability of y* to be used in the estimation of the RBE of cell killing for heavy-ion irradiations, which is of great importance in the treatment planning of charged-particle therapy. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 143, 号 2/4, p. 491-496, 発行日 2010-12 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/rpd/ncq484 | |||||
