@article{oai:repo.qst.go.jp:00046179,
 author = {Sato, Tatsuhiko and Watanabe, Ritsuko and Kase, Yuki and Tsuruoka, Chizuru and Suzuki, Masao and Furusawa, Yoshiya and Niita, Koji and 鶴岡 千鶴 and 鈴木 雅雄 and 古澤 佳也},
 issue = {2/4},
 journal = {Radiation Protection Dosimetry},
 month = {Dec},
 note = {It is considered that the linear energy transfer (LET) may not be the ideal index for expressing the relative biological effective- ness (RBE) of cell killing for heavy-ion irradiation, as the ion-species dependencies have clearly been observed in the relation between LET and RBE derived from cell-survival fraction data. The previously measured survival fractions of four cell lines irra- diated by various ion species, employing the saturation-corrected dose-mean lineal energy, y*, instead of LET as the index of the RBE were therefore re-analysed. In the analysis, the initial slopes of the survival fractions, the so-called a-parameter in the linear-quadratic model, were plotted as a function of y*, which was calculated by the microdosimetric kinetic (MK) model implemented in the Particle and Heavy Ion Transport code System. It was found from the analysis that the ion-species depen- dencies observed in the relations between a and LET disappeared from those between a and y*, and their relations can be well reproduced by a simple equation derived from the MK model. These results clearly indicate the suitability of y* to be used in the estimation of the RBE of cell killing for heavy-ion irradiations, which is of great importance in the treatment planning of charged-particle therapy.},
 pages = {491--496},
 title = {ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM},
 volume = {143},
 year = {2010}
}