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Carbon ion Radiation Therapy Improves the Prognosis of Unresectable Adult Bone and Soft Tissue Sarcoma of the Head and Neck
https://repo.qst.go.jp/records/46167
https://repo.qst.go.jp/records/461674275081f-27b2-4300-bf11-ffbfd91d01db
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-09-02 | |||||
| タイトル | ||||||
| タイトル | Carbon ion Radiation Therapy Improves the Prognosis of Unresectable Adult Bone and Soft Tissue Sarcoma of the Head and Neck | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Jingu, Keiichi
× Jingu, Keiichi× Tsujii, Hirohiko× Mizoe, Junetsu× Hasegawa, Azusa× Bessho, Hiroki× Takagi, Ryo× Morikawa, Takamichi× Tonogi, Morio× Tsuji, Hiroshi× Kamada, Tadashi× Yamada, Syougo× 神宮 啓一× 辻井 博彦× 溝江 純悦× 長谷川 安都佐× 別所 央城× 高木 亮× 森川 貴迪× 外木 守雄× 辻 比呂志× 鎌田 正× 山田 章吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) with 70.4 GyE for unresectable bone and soft-tissue sarcoma of the adult head and neck. \nMETHODS AND MATERIALS: Twenty-seven patients (mean age, 46.2 years) were enrolled in this prospective study on C-ion RT with 70.4 GyE/16 fractions (fr) between April 2001 and February 2008. The primary end points were acute and late reactions of normal tissues, local control rate, and overall survival rate. The secondary end point was efficacy of the treatment in comparison to historical results with 57.6 or 64.0 GyE/16 fr. \nRESULTS: The 3-year local control rate and overall survival rate for all patients were 91.8% (95% confidence interval [CI] = 81.0-100%) and 74.1% (95% CI = 57.5-90.6%), respectively. Acute reaction of Grade 3 or more was observed in only 1 patient. With regard to late reactions, visual loss was observed in 1 patient and a Grade 3 reaction of the maxillary bone was observed in 4 patients. A comparison with historical results revealed that the local control rate with 70.4 GyE was significantly higher than that with 57.6 or 64.0 GyE (3-year, 91.8% vs. 23.6%, p < 0.0001). Furthermore, the overall survival with 70.4 GyE tended to be higher than that with 57.6 or 64.0 GyE (3-year, 74.1% vs. 42.9%, p = 0.09). \nCONCLUSION: C-ion RT with 70.4 GyE/16 fr for bone and soft-tissue sarcoma of the adult head and neck appears to be effective with acceptable toxicities in comparison to conventional RT and C-ion RT with lower doses. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 82, 号 5, p. 2125-2131, 発行日 2011-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2010.08.043 | |||||
