@article{oai:repo.qst.go.jp:00046167,
 author = {Jingu, Keiichi and Tsujii, Hirohiko and Mizoe, Junetsu and Hasegawa, Azusa and Bessho, Hiroki and Takagi, Ryo and Morikawa, Takamichi and Tonogi, Morio and Tsuji, Hiroshi and Kamada, Tadashi and Yamada, Syougo and 神宮 啓一 and 辻井 博彦 and 溝江 純悦 and 長谷川 安都佐 and 別所 央城 and 高木 亮 and 森川 貴迪 and 外木 守雄 and 辻 比呂志 and 鎌田 正 and 山田 章吾},
 issue = {5},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Jul},
 note = {PURPOSE: To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) with 70.4 GyE for unresectable bone and soft-tissue sarcoma of the adult head and neck.
\nMETHODS AND MATERIALS: Twenty-seven patients (mean age, 46.2 years) were enrolled in this prospective study on C-ion RT with 70.4 GyE/16 fractions (fr) between April 2001 and February 2008. The primary end points were acute and late reactions of normal tissues, local control rate, and overall survival rate. The secondary end point was efficacy of the treatment in comparison to historical results with 57.6 or 64.0 GyE/16 fr.
\nRESULTS: The 3-year local control rate and overall survival rate for all patients were 91.8% (95% confidence interval [CI] = 81.0-100%) and 74.1% (95% CI = 57.5-90.6%), respectively. Acute reaction of Grade 3 or more was observed in only 1 patient. With regard to late reactions, visual loss was observed in 1 patient and a Grade 3 reaction of the maxillary bone was observed in 4 patients. A comparison with historical results revealed that the local control rate with 70.4 GyE was significantly higher than that with 57.6 or 64.0 GyE (3-year, 91.8% vs. 23.6%, p < 0.0001). Furthermore, the overall survival with 70.4 GyE tended to be higher than that with 57.6 or 64.0 GyE (3-year, 74.1% vs. 42.9%, p = 0.09).
\nCONCLUSION: C-ion RT with 70.4 GyE/16 fr for bone and soft-tissue sarcoma of the adult head and neck appears to be effective with acceptable toxicities in comparison to conventional RT and C-ion RT with lower doses.},
 pages = {2125--2131},
 title = {Carbon ion Radiation Therapy Improves the Prognosis of Unresectable Adult Bone and Soft Tissue Sarcoma of the Head and Neck},
 volume = {82},
 year = {2011}
}