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INDUCTION OF DNA DSB AND ITS REJOINING IN CLAMPED AND NON-CLAMPED TUMOURS AFTER EXPOSURE TO CARBON ION BEAMS IN COMPARISON TO X RAYS
https://repo.qst.go.jp/records/46091
https://repo.qst.go.jp/records/46091261447ea-d623-4ea2-9344-ff81aaebd09f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-06 | |||||
| タイトル | ||||||
| タイトル | INDUCTION OF DNA DSB AND ITS REJOINING IN CLAMPED AND NON-CLAMPED TUMOURS AFTER EXPOSURE TO CARBON ION BEAMS IN COMPARISON TO X RAYS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Uzawa, Akiko× Matsumoto, Yoshitaka× Noguchi, Miho× Kase, Yuki× Takase, Nobuhiro× Ito, Atsushi× Koike, Sachiko× Ando, Koichi× Okayasu, Ryuichi× Furusawa, Yoshiya× 平山 亮一× 鵜澤 玲子× 松本 孔貴× 伊藤 敦× 小池 幸子× 岡安 隆一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We studied DSB induction and rejoining in the clamped and non-clamped transplanted tumors in mice leg after 80 keV/µm carbon ions and X-rays. The yields of DSB in the tumors were analyzed by a static-field gel electrophoresis. The OER of DSB after X-rays was 1.68 +/- 0.31, and this value was not changed by one hour rejoining time (1.40 +/- 0.26). These damages in oxygenated conditions were rejoined 60 to 70% within one hour in situ. On the other hand, no difference between X-rays and carbon ions was found for the induction and rejoining of DSB. Thus, the values of OER and rejoined fraction after carbon ions were similar to that after X-rays, and the calculated RBEs of carbon ion were around 1 under both oxygen conditions. The yields of DSB in vivo depend on exposure doses, oxygen conditions and rejoining time, but not the types of radiation quality. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 143, 号 2-4, p. 508-512, 発行日 2011-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
